TY - JOUR
T1 - Calodioscurins A and B, two new isoprenylated xanthones from the stem bark of Calophyllum dioscurii P.F. Stevens
AU - Tjahjandarie, Tjitjik Srie
AU - Tanjung, Mulyadi
AU - Rahmania, Dhaniar Farah
AU - Rhidoma, Churin In
AU - Saputri, Ratih Dewi
N1 - Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Two new isoprenylated xanthones, calodioscurin A (1) and B (2) were isolated from the stem bark of Calophyllum dioscurii P.F. Stevens along with two known isoprenylated 4-phenylcoumarins, apetalolide (3) and methyl inophyllum P (4). The structures of two new compounds were determined based on their HRESIMS, IR, UV, 1D and 2D NMR spectral data. Compounds 1–4 were assayed on P-388 cells, compound 2 showed IC50 value 11.5 μM and categorised moderate activity.
AB - Two new isoprenylated xanthones, calodioscurin A (1) and B (2) were isolated from the stem bark of Calophyllum dioscurii P.F. Stevens along with two known isoprenylated 4-phenylcoumarins, apetalolide (3) and methyl inophyllum P (4). The structures of two new compounds were determined based on their HRESIMS, IR, UV, 1D and 2D NMR spectral data. Compounds 1–4 were assayed on P-388 cells, compound 2 showed IC50 value 11.5 μM and categorised moderate activity.
KW - Calodioscurins A and B
KW - Calophyllum dioscurii
KW - P-388 cell
KW - isoprenylated xanthone
UR - http://www.scopus.com/inward/record.url?scp=85103364739&partnerID=8YFLogxK
U2 - 10.1080/14786419.2019.1643864
DO - 10.1080/14786419.2019.1643864
M3 - Article
C2 - 31328544
AN - SCOPUS:85103364739
SN - 1478-6419
VL - 35
SP - 1153
EP - 1158
JO - Natural Product Research
JF - Natural Product Research
IS - 7
ER -