Caffeine Intake Decreases Osteoclastogenesis in Alveolar Bone Post Extraction

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Coffee is one of the most common dietary beverages in the world, it is the main natural source of caffeine in the diet. Clinical research suggests that drinking coffee, which contains Caffeine, along with antioxidants and other active components, are all found in coffee. Some research findings that Coffee has been shown to reduce the risk of pathological conditions, and because of that, these positive physiologic impacts coffee appear to be roughly related to serum levels of cytokines biomarkers, coffee might indeed presumably influence its preventative effects by reducing inflammation. In vitro investigations have also indicated that caffeine has direct or indirect negative effects on osteoblasts. Wounds due to tooth extraction require fast healing so that complications do not occur after tooth extraction. Osteoclasts are an indicator to determine whether the healing of a tooth extraction wound is healing well or not. All of the studies were conducted on adult male Wistar rats n = 20, 250-280 g at the start of the study. There was a reduction in the number of osteoclasts in the wound area after tooth extraction after caffeine administration.

Original languageEnglish
Pages (from-to)624-627
Number of pages4
JournalJournal of International Dental and Medical Research
Issue number2
Publication statusPublished - 2023


  • Caffeine
  • alveolar bone
  • osteoclastogenesis


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