C-KIT mutation role in oral malignant melanoma pathway: A narrative review

Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Hernalia Martadila Putri

Research output: Contribution to journalReview articlepeer-review

Abstract

Aim: To investigate the role of the c-KIT mutation in oral malignant melanoma (OMM). Materials and Methods: The search strategy includes randomized control trials and clinical trials from the databases of PubMed Central, Cochrane, EBSCO, and MEDLINE from January 1999 to May 2019. A total of seven clinical trials that met all inclusion criteria were included in this systematic review. Results: A previous study found that c-KIT can initiate the activation variety of downstream pathways, including the MAPK/MEK and PI3K/AKT pathways, which play important roles in cancer development. The c-KIT mutation has resulted in a loss of heterozygosity at 12p13, and loss of p27KIP1 protein has been detected. Activating c-KIT mutations in the juxtamembrane and other domains has been considered as an oncogene and also a therapeutic target in various tumors. Conclusion: c-KIT is playing the role of an important target in the research of molecular therapy in patients with metastatic OMM with c-KIT mutations.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalJournal of International Oral Health
Volume13
Issue number5
DOIs
Publication statusPublished - 1 Sept 2021

Keywords

  • OMM
  • Oral Lesion
  • Pathway
  • c-KIT Mutation

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