Brotowali extract (Tinospora crispa) for oral traumatic ulcer in diabetes mellitus Wistar Rat

Retno Indrawati Roestamadji, Ira Arundina, Indeswati Diyatri, Dewi Tamara Sambodo, Wahyuning Ratih Irmalia

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


One of the diabetes complication is delayed wound healing in oral traumatic ulcer. Tinospora crispa contains flavonoid and terpenoid which can help to control blood glucose level and accelerate wound healing. The aim of this study is to analyze brotowali (Tinospora crispa) extract potential in controlling blood glucose level and accelerating ulcer healing process. The extract was made with oven-dried method at 50°C and macerated with ethanol 80% (1:10 w/v). The rats were divided into 3 groups, control group I (K1) normal Wistar Rat with traumatic ulcer, control group II (K2) diabetes mellitus wistar rat with traumatic ulcer, and treatment group (P) diabetes mellitus wistar rat with traumatic ulcer treated with 250 mg/kg tinospora crispa extract once a day. Sample were euthanized on 3rd, 5th, and, 7th day after traumatic ulcer was made then a histopathology preparation was made to count fibroblast cell. Blood glucose level measurement was conducted on 3rd, 5th, 7th, and 14th after traumatic ulcer was made. Brotowali extract can affect blood glucose levels but make no significant difference and affect the number of fibroblasts in traumatic ulcers healing diabetes mellitus Wistar rats with significant difference.

Original languageEnglish
Pages (from-to)991-996
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number3
Publication statusPublished - 2017


  • Diabetes mellitus
  • Fibroblast cell
  • Tinosporacrispa
  • Traumatic ulcer
  • Wound healing


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