Breast cancer subtypes and disease-free interval in early-stage breast cancer

Risa Yolanda Matulessy, Heru Purwanto, Edwin Danardono

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: A meta-analysis study states that around 20%-30% of early breast cancer patients who have undergone surgery experience a recurrence in the first two years. This study aimed to analyze the subtype of breast cancer affecting the disease-free period in early breast cancer. Methods: This was a retrospective cohort study using data from the medical records of Dr. Soetomo Hospital, Surabaya, Indonesia. Subjects were patients with early-stage breast cancer who underwent a mastectomy and received additional therapy, evaluated for recurrence from clinical, radiological, and pathological markers. Results: This study found the luminal subtype had a longer disease-free interval (DFI) than non-luminal, but statistically, the cancer subtype was not associated with a disease-free period with a value of p = 0.917. Observation of the disease-free period for 12 months in the population we studied found recurrence appeared in 31 study subjects with 22 luminal subtypes and 9 non-luminal people where distant recurrence (12.2%) had the most targeted lung organs. Conclusion: Locoregional and distant recurrence in the luminal subtype group was significantly affected by angioinvasion, while it was not found in the non-luminal group.

Original languageEnglish
Pages (from-to)2539-2544
Number of pages6
JournalEurAsian Journal of BioSciences
Volume14
Issue number1
Publication statusPublished - 1 Jan 2020

Keywords

  • Breast cancer subtype
  • Disease-free interval
  • Recurrence

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