In the field of neurosurgery, duraplasty is commonly performed after intradural surgery which requires excision of the dura mater and/ or in the case of head injury. Over the past century, several biomaterials have been investigated as a dural substitute for duraplasty. Bovine pericardium (xenograft) has been widely studied in clinical trials and is commercialized as a graft in cardiac surgery, as well as a dural substitute. Bovine pericardium as a dural substitute is elastic, suturable, and provides watertight capabilities. Another biomaterial that also has many biologic advantages is chitosan. Chitosan has been widely known as a good agent for wound healing, because of its hemostatic properties and its ability in reducing inflammation. The availability and benefits of both materials make it an interesting subject for further research. This review aims to provides knowledge about the potential bovine pericardium in combination with chitosan as a dural substitute, which not only provides watertight properties, but also accelerates tissue healing in dural defects.

Original languageEnglish
Pages (from-to)102-109
Number of pages8
JournalMalaysian Journal of Medicine and Health Sciences
Publication statusPublished - Sept 2021


  • Bovine Pericardium
  • Chitosan
  • Dural Substitute
  • Tissue Healing
  • Xenograft


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