Bisindole alkaloids from Voacanga grandifolia leaves

Alfarius Eko Nugroho; Yurika Ono; Eunji Jin; Yusuke Hirasawa; Toshio Kaneda; Abdul Rahman; Idha Kusumawati; Takahiro Tougan; Toshihiro Horii; Noor Cholies Zaini; Hiroshi Morita

doi:10.1007/s11418-020-01475-w

Bisindole alkaloids from Voacanga grandifolia leaves

Alfarius Eko Nugroho, Yurika Ono, Eunji Jin, Yusuke Hirasawa, Toshio Kaneda, Abdul Rahman, Idha Kusumawati, Takahiro Tougan, Toshihiro Horii, Noor Cholies Zaini, Hiroshi Morita

Research output: Contribution to journal › Comment/debate

16 Citations (Scopus)

Abstract

Abstract: Two new bisindole alkaloids, 12′-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	408-414
Number of pages	7
Journal	Journal of Natural Medicines
Volume	75
Issue number	2
DOIs	https://doi.org/10.1007/s11418-020-01475-w
Publication status	Published - Mar 2021

Keywords

Antimalarial activity
Apocynaceae
Bisindole alkaloids
Voacanga grandifolia

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10.1007/s11418-020-01475-w

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@article{94384b5ba4e842b4810891e15f550c5c,

title = "Bisindole alkaloids from Voacanga grandifolia leaves",

abstract = "Abstract: Two new bisindole alkaloids, 12′-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells. Graphical abstract: [Figure not available: see fulltext.]",

keywords = "Antimalarial activity, Apocynaceae, Bisindole alkaloids, Voacanga grandifolia",

author = "Nugroho, {Alfarius Eko} and Yurika Ono and Eunji Jin and Yusuke Hirasawa and Toshio Kaneda and Abdul Rahman and Idha Kusumawati and Takahiro Tougan and Toshihiro Horii and Zaini, {Noor Cholies} and Hiroshi Morita",

note = "Publisher Copyright: {\textcopyright} 2021, The Japanese Society of Pharmacognosy.",

year = "2021",

month = mar,

doi = "10.1007/s11418-020-01475-w",

language = "English",

volume = "75",

pages = "408--414",

journal = "Journal of Natural Medicines",

issn = "1340-3443",

publisher = "Springer Japan",

number = "2",

}

TY - JOUR

T1 - Bisindole alkaloids from Voacanga grandifolia leaves

AU - Nugroho, Alfarius Eko

AU - Ono, Yurika

AU - Jin, Eunji

AU - Hirasawa, Yusuke

AU - Kaneda, Toshio

AU - Rahman, Abdul

AU - Kusumawati, Idha

AU - Tougan, Takahiro

AU - Horii, Toshihiro

AU - Zaini, Noor Cholies

AU - Morita, Hiroshi

PY - 2021/3

Y1 - 2021/3

N2 - Abstract: Two new bisindole alkaloids, 12′-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells. Graphical abstract: [Figure not available: see fulltext.]

AB - Abstract: Two new bisindole alkaloids, 12′-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells. Graphical abstract: [Figure not available: see fulltext.]

KW - Antimalarial activity

KW - Apocynaceae

KW - Bisindole alkaloids

KW - Voacanga grandifolia

UR - http://www.scopus.com/inward/record.url?scp=85100196103&partnerID=8YFLogxK

U2 - 10.1007/s11418-020-01475-w

DO - 10.1007/s11418-020-01475-w

M3 - Comment/debate

C2 - 33462757

AN - SCOPUS:85100196103

SN - 1340-3443

VL - 75

SP - 408

EP - 414

JO - Journal of Natural Medicines

JF - Journal of Natural Medicines

IS - 2

ER -

Bisindole alkaloids from Voacanga grandifolia leaves

Abstract

Keywords

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