Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa

Kazumasa Zaima; Tomoko Hirata; Takahiro Hosoya; Yusuke Hirasawa; Koichiro Koyama; Abdul Rahman; Idha Kusumawati; Noor Cholies Zaini; Motoo Shiro; Hiroshi Morita

doi:10.1021/np900365r

Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa

Kazumasa Zaima, Tomoko Hirata, Takahiro Hosoya, Yusuke Hirasawa, Koichiro Koyama, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Motoo Shiro, Hiroshi Morita

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.

Original language	English
Pages (from-to)	1686-1690
Number of pages	5
Journal	Journal of Natural Products
Volume	72
Issue number	9
DOIs	https://doi.org/10.1021/np900365r
Publication status	Published - 25 Sept 2009

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Zaima, K., Hirata, T., Hosoya, T., Hirasawa, Y., Koyama, K., Rahman, A., Kusumawati, I., Zaini, N. C., Shiro, M., & Morita, H. (2009). Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa. Journal of Natural Products, 72(9), 1686-1690. https://doi.org/10.1021/np900365r

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title = "Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa",

abstract = "Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.",

author = "Kazumasa Zaima and Tomoko Hirata and Takahiro Hosoya and Yusuke Hirasawa and Koichiro Koyama and Abdul Rahman and Idha Kusumawati and Zaini, {Noor Cholies} and Motoo Shiro and Hiroshi Morita",

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Zaima, K, Hirata, T, Hosoya, T, Hirasawa, Y, Koyama, K, Rahman, A, Kusumawati, I, Zaini, NC, Shiro, M & Morita, H 2009, 'Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa', Journal of Natural Products, vol. 72, no. 9, pp. 1686-1690. https://doi.org/10.1021/np900365r

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AU - Zaima, Kazumasa

AU - Hirata, Tomoko

AU - Hosoya, Takahiro

AU - Hirasawa, Yusuke

AU - Koyama, Koichiro

AU - Rahman, Abdul

AU - Kusumawati, Idha

AU - Zaini, Noor Cholies

AU - Shiro, Motoo

AU - Morita, Hiroshi

PY - 2009/9/25

Y1 - 2009/9/25

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AB - Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.

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Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa

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