TY - JOUR
T1 - Biopolymer-based polycaprolactone-hydroxyapatite scaffolds for bone tissue engineering
AU - Aminatun,
AU - Suciati, Tri
AU - Sari, Yessie Widya
AU - Sari, Mona
AU - Alamsyah, Kartika A.
AU - Purnamasari, Wulan
AU - Yusuf, Yusril
N1 - Funding Information:
This work was supported by the Riset Kolaborasi Indonesia (RKI) Program of the Ministry of Education and Culture Republic of Indonesia. The authors are immensely grateful to the Riset Kolaborasi Indonesia (RKI) Program of Universitas Airlangga for financially supporting this research. The authors acknowledge the use of the facilities and the technical assistance of the Biomedical Technology Laboratory Faculty of Science and Technology, the Research Center Faculty of Dental Medicine, and the Material Physics Laboratory at the Universitas Airlangga, and the Material Physics and Electronics Laboratory and staff of the Integrated Laboratory for Research and Testing at the Universitas Gadjah Mada, Indonesia.
Funding Information:
The authors are immensely grateful to the Riset Kolaborasi Indonesia (RKI) Program of Universitas Airlangga for financially supporting this research. The authors acknowledge the use of the facilities and the technical assistance of the Biomedical Technology Laboratory Faculty of Science and Technology, the Research Center Faculty of Dental Medicine, and the Material Physics Laboratory at the Universitas Airlangga, and the Material Physics and Electronics Laboratory and staff of the Integrated Laboratory for Research and Testing at the Universitas Gadjah Mada, Indonesia.
Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - This work synthesized Hydroxyapatite (HA) from common cockle shells using a precipitation method and fabricated nanofiber scaffolds of polycaprolactone (PCL)-HA composites with combinations of several polymers (i.e., gelatin, chitosan, and collagen) using electrospinning. The synthesized HA had a small agglomerate shape, solid structure, and few interconnected micropores. Energy Dispersive X-Ray Spectroscopy (EDS) analysis revealed that the synthesized HA exhibited a Ca/P molar ratio of 1.68. All nanofiber samples were nontoxic with cell viability values of 70.46–91.78%. The PCL-HA-Gelatin nanofiber was the best mechanical properties of the scaffold with the high values of tensile strength, modulus of elasticity, and breaking-point elongation at (9.80 ± 1.36) MPa, (0.81 ± 0.09) MPa, and (61.5 ± 7.75) %, respectively. There was no significant difference in the average cell viability of the samples. Nanofiber scaffolds of PCL-HA polymer have the potential for bone tissue engineering applications by satisfying their mechanical property and cytotoxicity assay criteria.
AB - This work synthesized Hydroxyapatite (HA) from common cockle shells using a precipitation method and fabricated nanofiber scaffolds of polycaprolactone (PCL)-HA composites with combinations of several polymers (i.e., gelatin, chitosan, and collagen) using electrospinning. The synthesized HA had a small agglomerate shape, solid structure, and few interconnected micropores. Energy Dispersive X-Ray Spectroscopy (EDS) analysis revealed that the synthesized HA exhibited a Ca/P molar ratio of 1.68. All nanofiber samples were nontoxic with cell viability values of 70.46–91.78%. The PCL-HA-Gelatin nanofiber was the best mechanical properties of the scaffold with the high values of tensile strength, modulus of elasticity, and breaking-point elongation at (9.80 ± 1.36) MPa, (0.81 ± 0.09) MPa, and (61.5 ± 7.75) %, respectively. There was no significant difference in the average cell viability of the samples. Nanofiber scaffolds of PCL-HA polymer have the potential for bone tissue engineering applications by satisfying their mechanical property and cytotoxicity assay criteria.
KW - Bone tissue engineering
KW - common cockle shells
KW - composite nanofiber scaffold
KW - hydroxyapatite
UR - http://www.scopus.com/inward/record.url?scp=85121765006&partnerID=8YFLogxK
U2 - 10.1080/00914037.2021.2018315
DO - 10.1080/00914037.2021.2018315
M3 - Article
AN - SCOPUS:85121765006
SN - 0091-4037
VL - 72
SP - 376
EP - 385
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 5
ER -