TY - JOUR
T1 - Biopolymer-based polycaprolactone-hydroxyapatite scaffolds for bone tissue engineering
AU - Aminatun,
AU - Suciati, Tri
AU - Sari, Yessie Widya
AU - Sari, Mona
AU - Alamsyah, Kartika A.
AU - Purnamasari, Wulan
AU - Yusuf, Yusril
N1 - Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - This work synthesized Hydroxyapatite (HA) from common cockle shells using a precipitation method and fabricated nanofiber scaffolds of polycaprolactone (PCL)-HA composites with combinations of several polymers (i.e., gelatin, chitosan, and collagen) using electrospinning. The synthesized HA had a small agglomerate shape, solid structure, and few interconnected micropores. Energy Dispersive X-Ray Spectroscopy (EDS) analysis revealed that the synthesized HA exhibited a Ca/P molar ratio of 1.68. All nanofiber samples were nontoxic with cell viability values of 70.46–91.78%. The PCL-HA-Gelatin nanofiber was the best mechanical properties of the scaffold with the high values of tensile strength, modulus of elasticity, and breaking-point elongation at (9.80 ± 1.36) MPa, (0.81 ± 0.09) MPa, and (61.5 ± 7.75) %, respectively. There was no significant difference in the average cell viability of the samples. Nanofiber scaffolds of PCL-HA polymer have the potential for bone tissue engineering applications by satisfying their mechanical property and cytotoxicity assay criteria.
AB - This work synthesized Hydroxyapatite (HA) from common cockle shells using a precipitation method and fabricated nanofiber scaffolds of polycaprolactone (PCL)-HA composites with combinations of several polymers (i.e., gelatin, chitosan, and collagen) using electrospinning. The synthesized HA had a small agglomerate shape, solid structure, and few interconnected micropores. Energy Dispersive X-Ray Spectroscopy (EDS) analysis revealed that the synthesized HA exhibited a Ca/P molar ratio of 1.68. All nanofiber samples were nontoxic with cell viability values of 70.46–91.78%. The PCL-HA-Gelatin nanofiber was the best mechanical properties of the scaffold with the high values of tensile strength, modulus of elasticity, and breaking-point elongation at (9.80 ± 1.36) MPa, (0.81 ± 0.09) MPa, and (61.5 ± 7.75) %, respectively. There was no significant difference in the average cell viability of the samples. Nanofiber scaffolds of PCL-HA polymer have the potential for bone tissue engineering applications by satisfying their mechanical property and cytotoxicity assay criteria.
KW - Bone tissue engineering
KW - common cockle shells
KW - composite nanofiber scaffold
KW - hydroxyapatite
UR - http://www.scopus.com/inward/record.url?scp=85121765006&partnerID=8YFLogxK
U2 - 10.1080/00914037.2021.2018315
DO - 10.1080/00914037.2021.2018315
M3 - Article
AN - SCOPUS:85121765006
SN - 0091-4037
VL - 72
SP - 376
EP - 385
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 5
ER -