Biomarker Profiles Associated with Covid-19 Mortality in East Java, Indonesia: A Tertiary Care Hospital Study

Retno Budiarti; Ediono; Muhammad Miftahussurur; Abdulloh Machin; Wiwin Is Effendi; Mochammad Wijdan Rosyich; Ayu Imamatun Nisa; Fatimatuzzahro; Nila Novia Putri; Muhammad Ja far Shodiq

doi:10.5530/pj.2024.16.110

Biomarker Profiles Associated with Covid-19 Mortality in East Java, Indonesia: A Tertiary Care Hospital Study

Retno Budiarti, Ediono, Muhammad Miftahussurur, Abdulloh Machin, Wiwin Is Effendi, Mochammad Wijdan Rosyich, Ayu Imamatun Nisa, Fatimatuzzahro, Nila Novia Putri, Muhammad Ja far Shodiq

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: This study aimed to compare the most useful biomarkers for predicting prognosis and response to therapy in COVID-19 patients. Material and Methods: This quantitative study involved 639 patients who were hospitalized with COVID-19 infection. Patients without any biochemical marker result; patients referred to another hospital; and peripheral oxygen levels measured using oxygen supplementation were excluded from the study. Results: There was a statistically significant difference in terms of demographics, vital signs on admission, and laboratory parameters. The risk of mortality in COVID-19 is significantly influenced by c-reactive protein (CRP) and interleukin-6 (IL-6) levels (p-value <0.05). Conclusion: Findings revealed these biomarkers could help the future development of more personalized treatment and diagnostic approaches.

Original language	English
Pages (from-to)	689-694
Number of pages	6
Journal	Pharmacognosy Journal
Volume	16
Issue number	3
DOIs	https://doi.org/10.5530/pj.2024.16.110
Publication status	Published - May 2024

Keywords

Biomarker
COVID-19
Outcome

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10.5530/pj.2024.16.110

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title = "Biomarker Profiles Associated with Covid-19 Mortality in East Java, Indonesia: A Tertiary Care Hospital Study",

abstract = "Objective: This study aimed to compare the most useful biomarkers for predicting prognosis and response to therapy in COVID-19 patients. Material and Methods: This quantitative study involved 639 patients who were hospitalized with COVID-19 infection. Patients without any biochemical marker result; patients referred to another hospital; and peripheral oxygen levels measured using oxygen supplementation were excluded from the study. Results: There was a statistically significant difference in terms of demographics, vital signs on admission, and laboratory parameters. The risk of mortality in COVID-19 is significantly influenced by c-reactive protein (CRP) and interleukin-6 (IL-6) levels (p-value <0.05). Conclusion: Findings revealed these biomarkers could help the future development of more personalized treatment and diagnostic approaches.",

keywords = "Biomarker, COVID-19, Outcome",

author = "Retno Budiarti and Ediono and Muhammad Miftahussurur and Abdulloh Machin and Effendi, {Wiwin Is} and Rosyich, {Mochammad Wijdan} and Nisa, {Ayu Imamatun} and Fatimatuzzahro and Putri, {Nila Novia} and Shodiq, {Muhammad Ja far}",

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year = "2024",

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doi = "10.5530/pj.2024.16.110",

language = "English",

volume = "16",

pages = "689--694",

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T1 - Biomarker Profiles Associated with Covid-19 Mortality in East Java, Indonesia

T2 - A Tertiary Care Hospital Study

AU - Budiarti, Retno

AU - Ediono,

AU - Miftahussurur, Muhammad

AU - Machin, Abdulloh

AU - Effendi, Wiwin Is

AU - Rosyich, Mochammad Wijdan

AU - Nisa, Ayu Imamatun

AU - Fatimatuzzahro,

AU - Putri, Nila Novia

AU - Shodiq, Muhammad Ja far

PY - 2024/5

Y1 - 2024/5

N2 - Objective: This study aimed to compare the most useful biomarkers for predicting prognosis and response to therapy in COVID-19 patients. Material and Methods: This quantitative study involved 639 patients who were hospitalized with COVID-19 infection. Patients without any biochemical marker result; patients referred to another hospital; and peripheral oxygen levels measured using oxygen supplementation were excluded from the study. Results: There was a statistically significant difference in terms of demographics, vital signs on admission, and laboratory parameters. The risk of mortality in COVID-19 is significantly influenced by c-reactive protein (CRP) and interleukin-6 (IL-6) levels (p-value <0.05). Conclusion: Findings revealed these biomarkers could help the future development of more personalized treatment and diagnostic approaches.

AB - Objective: This study aimed to compare the most useful biomarkers for predicting prognosis and response to therapy in COVID-19 patients. Material and Methods: This quantitative study involved 639 patients who were hospitalized with COVID-19 infection. Patients without any biochemical marker result; patients referred to another hospital; and peripheral oxygen levels measured using oxygen supplementation were excluded from the study. Results: There was a statistically significant difference in terms of demographics, vital signs on admission, and laboratory parameters. The risk of mortality in COVID-19 is significantly influenced by c-reactive protein (CRP) and interleukin-6 (IL-6) levels (p-value <0.05). Conclusion: Findings revealed these biomarkers could help the future development of more personalized treatment and diagnostic approaches.

KW - Biomarker

KW - COVID-19

KW - Outcome

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JO - Pharmacognosy Journal

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IS - 3

ER -

Biomarker Profiles Associated with Covid-19 Mortality in East Java, Indonesia: A Tertiary Care Hospital Study

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Keywords

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