Biological study of piper crocatum leaves ethanol extract improving the skin histopathology of wistar rat wound infected by staphylococcus aureus

The wound is a continuous damage on mucosal membrane or bone and another organ which cause a traumatic effect. This biological study aim was to investigate the effect of red betel leaves ethanol extract (Piper crocatum) to the skin histopathology of Wistar rat infected by Staphylococcus aureus. The experimental research used Randomized Post Test. Wistar male rats were divided into 5 group: P0 (control), P1 (Povidone iodine), P2 (50% of P. crocatum leaves extract), P3 (25% of P. crocatum leaves extract), and P4 (12.5% of P. crocatum leaves extract). The number of neutrophils, macrophage, fibroblast, and angiogenesis were analyzed by ANOVA and LSD. Collagen density was analyzed by Kruskal-Wallis test and Mann-Whitney test. This study proved that P4 group (12.5% of P. crocatum leaves extract) improved the skin histopathology of rat wound infected by S. aureus.