Biological Properties of Gynura procumbens Leaves Extract to MDA Levels and Antioxidant Activities in Liver of Mice

Sugiharto, Anjar Tri Wibowo, Ummi Zubaidah, Annisa Dwi Savitri, Muhammad Sidqon Faukib, Navy Safira Salsabila, Yosephine Sri Wulan Manuhara

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The objective of our research was to the evaluated biological activities of G. procumbens leaves methanol extract (GLME) for the hepatoprotective against cadmium (Cd) toxicity in mice. Research was performed using twenty five healthy male mice, which were grouped into five treatments: P1 (control), P2 (Cd-100mg/L), P3 (GLME100mg/L+Cd-100mg/L), P4 (GLME-200mg/L+Cd-100mg/L), P5 (GLME-300mg/L+Cd-100mg/L). The results showed GLME contain phenolic and flavonoids compound by total phenolic content (TPC) and total flavonoid content (TFC) assay, they were strongly correlated with antioxidant activities. In this study, it was also known that Cd exposure increasing malondialdehyde (MDA) level and decreasing of superoxide dismutase (SOD) and catalase (CAT) activities in liver homogenates compared to control significantly. This is in line with a decreased in the number of normal cells and slightly an increased in damage cells in the histological hepatic cells. Administration of GLME can prevent liver cell damage due to Cd treatment by increasing the number of histological normal cells and the activities of SOD and CAT enzyme and reducing the level of MDA in liver homogenates. The best treatment of GLME was 100mg/L.

Original languageEnglish
Pages (from-to)5829-5834
Number of pages6
JournalResearch Journal of Pharmacy and Technology
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Antioxidant activity
  • Gynura procumbens
  • Health care
  • Hepatoprotective
  • MDA

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