Abstract
The synthesis of collagen-hydroxyapatite composites has been carried out, and the biocompatibility and osteoconductivity properties have been tested. This research was conducted to determine the ability of hydroxyapatite-collagen composites to support the bone growth through the graft surface. Hydroxyapatite used in this study was synthesized from coral with a purity of 96.6%, while collagen was extracted from the chicken claw. The process of forming a scaffold of collagen-hydroxyapatite composites was carried out using the freeze-drying method at -80°C for 4 h. The biocompatibility characteristics of the sample through the cytotoxicity tests showed that the percentage of viable cells in collagen-hydroxyapatite biocomposite was 108.2%, which is higher than the percentage of viable cells of hydroxyapatite or collagen material. When the viable cell is above 100%, collagen-hydroxyapatite composites have excellent osteoconductivity as a material for bone regeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 584-590 |
| Number of pages | 7 |
| Journal | Open Chemistry |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2020 |
Keywords
- biocompatibility
- composite
- coral
- osteoconductivity