Better pandemic influenza preparedness through adjuvant technology transfer: Challenges and lessons learned

Céline H. Lemoine, Reviany V. Nidom, Roland Ventura, Setyarina Indrasari, Irine Normalina, Kuncoro Puguh Santoso, Francis Derouet, Christophe Barnier-Quer, Gerrit Borchard, Nicolas Collin, Chairul A. Nidom

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Adequate global vaccine coverage during an influenza pandemic is essential to mitigate morbidity, mortality, and economic impact. Vaccine development and production needs to be sufficient to meet a vast global demand, requiring international cooperation and local vaccine production capacity, especially in resource-constrained countries. The use of adjuvants is one approach to augment the number of available vaccine doses and to overcome potential vaccine shortages. Appropriately selected adjuvant technologies can decrease the amount of vaccine antigen required per dose, may broaden or lengthen the conferred protection against disease, and may even allow protective single-dose vaccination. Here we describe a technology transfer collaboration between Switzerland and Indonesia that led to the establishment of a vaccine formulation platform in Surabaya which involved the transfer of equipment and expertise to enable research and development of adjuvanted vaccine formulations and delivery systems. This new Indonesian capability aims to facilitate local and regional access to know-how relating to adjuvanted vaccine formulations, thus promoting their application to local vaccine developers. In this review, we aim to share the “lessons learned” from this project to both support and inspire future scientific collaborations of a similar nature.

Original languageEnglish
Article number461
JournalVaccines
Volume9
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • Adjuvanted vaccines
  • Global health
  • Influenza
  • Lessons learned
  • Pandemic preparedness
  • Technology transfer

Fingerprint

Dive into the research topics of 'Better pandemic influenza preparedness through adjuvant technology transfer: Challenges and lessons learned'. Together they form a unique fingerprint.

Cite this