TY - GEN
T1 - Beneficial Effect of Amniotic Membrane Stem Cell and Vitamin C after Fractional Carbon-Dioxide Laser for Photoaging Treatment in Asian Skin
AU - Umborowati, Menul Ayu
AU - Citrashanty, Irmadita
AU - Surono, Ingrid S.
AU - Sari, Maylita
AU - Endaryanto, Anang
AU - Prakoeswa, Cita Rosita Sigit
N1 - Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Background: Asia is located around equator with all year sun exposure. That is why Asians are more susceptible to aging caused by ultraviolet, or called as photoaging. Dyspigmentation and wrinkle is the most visible clinical sign of skin photoaging, making them the main target to treat.Objective: To investigate the efficacy of fractional Carbon Dioxide (CO2) laser-Assisted amniotic membrane stem cell conditioned medium (AMSC-CM) plus vitamin C in Asian skin photoaging.Patients and methods: This were a randomized comparative clinical study in photoaged patients. Experimental group received amniotic membrane stem cell conditioned medium (AMSC-CM) plus vitamin C mixture after fractional CO2 laser, while another group received AMSC-CM after fractional CO2 laser. The formulation was applied three times with 4 weeks interval. Fractional CO2 laser was used to assist epidermal penetration. Wrinkle, pore, spot, and skin tone were evaluated before treatment and 4 weeks after last session.Results: This study included 60 women with an average age of over 50 years. Wrinkle and pore improvement after therapy on AMSC-CM plus Vitamin C mixture group were significantly better than group who only received AMSC-CM (p value < 0.05). No serious adverse effect was observed during the study.Conclusion: AMSC-CM plus Vitamin C mixture application after laser fractional CO2 is promising as rejuvenation treatment in Asian skin.
AB - Background: Asia is located around equator with all year sun exposure. That is why Asians are more susceptible to aging caused by ultraviolet, or called as photoaging. Dyspigmentation and wrinkle is the most visible clinical sign of skin photoaging, making them the main target to treat.Objective: To investigate the efficacy of fractional Carbon Dioxide (CO2) laser-Assisted amniotic membrane stem cell conditioned medium (AMSC-CM) plus vitamin C in Asian skin photoaging.Patients and methods: This were a randomized comparative clinical study in photoaged patients. Experimental group received amniotic membrane stem cell conditioned medium (AMSC-CM) plus vitamin C mixture after fractional CO2 laser, while another group received AMSC-CM after fractional CO2 laser. The formulation was applied three times with 4 weeks interval. Fractional CO2 laser was used to assist epidermal penetration. Wrinkle, pore, spot, and skin tone were evaluated before treatment and 4 weeks after last session.Results: This study included 60 women with an average age of over 50 years. Wrinkle and pore improvement after therapy on AMSC-CM plus Vitamin C mixture group were significantly better than group who only received AMSC-CM (p value < 0.05). No serious adverse effect was observed during the study.Conclusion: AMSC-CM plus Vitamin C mixture application after laser fractional CO2 is promising as rejuvenation treatment in Asian skin.
KW - Amniotic membrane stem cell
KW - human and health
KW - laser
KW - photoaging
KW - vitamin C
UR - http://www.scopus.com/inward/record.url?scp=85166679214&partnerID=8YFLogxK
U2 - 10.1109/ICHE55634.2022.10179886
DO - 10.1109/ICHE55634.2022.10179886
M3 - Conference contribution
AN - SCOPUS:85166679214
T3 - 2022 International Conference on Healthcare Engineering, ICHE 2022 - Proceedings
BT - 2022 International Conference on Healthcare Engineering, ICHE 2022 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2022 International Conference on Healthcare Engineering, ICHE 2022
Y2 - 23 September 2022 through 25 September 2022
ER -