AST/ALT levels, MDA, and liver histopathology of Echinometra mathaei ethanol extract on paracetamol-induced hepatotoxicity in rats

Angelica Kresnamurti, Dita Nurlita Rakhma, Amitasari Damayanti, Septiyan Dwi Santoso, Enggar Restryarto, Wifqi Hadinata, Iwan Sahrial Hamid

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Echinometra mathaei was known to have potential antioxidant activities because it contains of polyhydroxy-naphthoquinone (echinochrome and spinochromes). The antioxidant properties contributed to the hepatoprotective effect by binding to free radicals compound that causes oxidative stress and necrosis in the hepatocytes. The research aimed to determine the hepatorepair effects of the E. mathaei ethanol extract on high-dose paracetamol-induced hepatic damage in Wistar rats. This research used a true experimental method. Thirty white male rats were divided into sixth groups, i.e., normal control group, group II-VI was induced paracetamol 2,000 mg/kg BW for three days. After paracetamol-induced, group III-VI was treated with curcumin 800 mg/kg BW, E. mathaei extract 400, 800, and 1,200 mg/kg BW for seven days. The hepatorepair parameter was obtained from AST/ALT, MDA tissue levels, and the number of hepatocyte necrosis cells. The data results were analyzed using the ANOVA test, followed by the LSD test to determine the difference between each treatment. The results showed that E. mathaei significantly (p<0.05) decreased the AST levels, MDA levels and the number of hepatocyte necrosis cells at a dose of 800 mg/kg BW per orally treatment. The E. mathaei ethanol extract repaired the hepatic damage induced by paracetamol.

Original languageEnglish
Pages (from-to)511-516
Number of pages6
JournalJournal of Basic and Clinical Physiology and Pharmacology
Volume32
Issue number4
DOIs
Publication statusPublished - 1 Jul 2021

Keywords

  • AST/ALT
  • Echinometra mathaei
  • MDA
  • Wistar rat
  • hepatocyte necrotic cell
  • hepatorepair
  • paracetamol-induced
  • sea urchin

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