Chronic inflammation can have a considerable impact on the progression of glomerular and tubulointerstitial pathologies in chronic kidney disease (CKD). As an alternative to the early detection of inflammatory biomarkers that are most prominent in the progression of CKD, analyzing the relationship of monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and tumor necrosis factor-α (TNF-α) in CKD is the goal of this study. This cross-sectional study involved 65 CKD subjects, consisting of 5 stages of CKD in compliance with KDIGO standards. Estimated glomerular filtration rate (eGFR) was calculated utilizing the CKD epidemiology collaboration (CKD-EPI) creatinine formulation. MLR and NLR were calculated from the differential count hematology analyzer. TNF-α was examined using the sandwich ELISA method. Random-spot urine was used for the UACR examination. There were significant differences in MLR and TNF-α at various stages of CKD, whereas NLR exhibited no significant difference at different stages of CKD. There was a significant association in MLR, NLR, and the stages of CKD. However, TNF-α was not associated with the stages of CKD. Also, MLR and NLR were not correlated with TNF-α in CKD. Furthermore, MLR, NLR, and TNF-α had no significant relationship with urine albumin-creatinine ratio (UACR). In conclusion, MLR is better for assessing CKD progression than NLR and TNF-α.

Original languageEnglish
Pages (from-to)346-356
Number of pages11
JournalJournal of Advanced Biotechnology and Experimental Therapeutics
Issue number2
Publication statusPublished - 2024


  • CKD
  • Inflammation
  • Monocyte-to-lymphocyte ratio
  • Neutrophil-to-lymphocyte ratio
  • TNF-α


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