TY - JOUR
T1 - Association of manganese superoxide dismutase Ala16Val gene polymorphism with diabetic retinopathy risk in type 2 diabetes
T2 - A systematic review and meta-analysis
AU - Nugrahani, Annisa Salsabilla Dwi
AU - Prabowo, Gwenny Ichsan
AU - Pranoto, Agung
AU - Wungu, Citrawati Dyah Kencono
AU - Wiratama, Bayu Satria
N1 - Publisher Copyright:
© 2024, Modestum LTD. All rights reserved.
PY - 2024/6
Y1 - 2024/6
N2 - Background: Diabetic retinopathy (DR) is renowned as a prominent cause of visual impairment worldwide. The association between manganese superoxide dismutase (MnSOD) gene, Ala16Val (rs4880), and DR susceptibility in people with type 2 diabetes mellitus (T2DM) remains contentious. Objective: This meta-analysis aims to evaluate risk of DR in T2DM patients with MnSOD Ala16Val polymorphism. Methods: A literature search was conducted using MEDLINE, Scopus, Web of Science, ScienceDirect, EMBASE, and grey literature to identify potential studies assessing the link between MnSOD polymorphism and DR risk among T2DM patients. The data was further analyzed in fixed/random effect models using RevMan 5.3 under five genetic models. Results: Six studies comprising 2,132 subjects from four distinct ethnicities were included. The present study revealed that MnSOD gene polymorphism was associated with a significantly increasing DR risk in T2DM patients under the co-dominant model (VV vs. AA) (OR 1.87 [1.42, 2.46], p<0.0001) and dominant model (VV+AV vs. AA) (OR 1.85 [1.02, 3.33], p=0.0400). Conclusions: T2DM individuals with rs4880 VV alleles are more susceptible to DR development, making them as a potential marker for heightened DR susceptibility in T2DM patients, laying the foundation for a gene panel to assess their susceptibility to develop DR.
AB - Background: Diabetic retinopathy (DR) is renowned as a prominent cause of visual impairment worldwide. The association between manganese superoxide dismutase (MnSOD) gene, Ala16Val (rs4880), and DR susceptibility in people with type 2 diabetes mellitus (T2DM) remains contentious. Objective: This meta-analysis aims to evaluate risk of DR in T2DM patients with MnSOD Ala16Val polymorphism. Methods: A literature search was conducted using MEDLINE, Scopus, Web of Science, ScienceDirect, EMBASE, and grey literature to identify potential studies assessing the link between MnSOD polymorphism and DR risk among T2DM patients. The data was further analyzed in fixed/random effect models using RevMan 5.3 under five genetic models. Results: Six studies comprising 2,132 subjects from four distinct ethnicities were included. The present study revealed that MnSOD gene polymorphism was associated with a significantly increasing DR risk in T2DM patients under the co-dominant model (VV vs. AA) (OR 1.87 [1.42, 2.46], p<0.0001) and dominant model (VV+AV vs. AA) (OR 1.85 [1.02, 3.33], p=0.0400). Conclusions: T2DM individuals with rs4880 VV alleles are more susceptible to DR development, making them as a potential marker for heightened DR susceptibility in T2DM patients, laying the foundation for a gene panel to assess their susceptibility to develop DR.
KW - diabetic retinopathy
KW - genetic polymorphism
KW - superoxide dismutase
KW - type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85202584058&partnerID=8YFLogxK
U2 - 10.29333/ejgm/14654
DO - 10.29333/ejgm/14654
M3 - Review article
AN - SCOPUS:85202584058
SN - 1304-3889
VL - 21
JO - Electronic Journal of General Medicine
JF - Electronic Journal of General Medicine
IS - 3
M1 - em592
ER -