Association of duration of valproic acid treatment and glycemic indexes among adult

Introduction: Valproic acid (VA) is one of the commonly used for epilepsy, psychiatric problems, and recurrent migraine medication. Long-term use of VA maybe affects the metabolic processes, resulting in the gain of weight and disturbance of glycemic indexes which play an important role in cardiovascular consequences. Unfortunately, these impacts have not been fully understood. The study investigates the long-term impact of VA on the level of fasting blood sugar, 2-hour after-meal blood sugar and HbA1C among adults. Methods: An observational study with the cross-sectional study approach among forty participants (n=21, with less than 1-year medication, and n=19, with the 1 year or more medication) who fulfill the inclusion and exclusion criteria. The level of fasting blood sugar, 2 hours after-meal blood sugar, and HbA1C levels were examined. The two-independent T-test was performed to determine the statistical differences of the level of the fasting blood sugar, 2-hour after-meal blood sugar, and HbA1C from both groups. Results: There are no significant differences in most of the demographic and clinical characteristics of participants except for age, and there are no significant differences in the level of fasting blood sugar, 2-hour after-meal blood sugar, and HbA1C among both groups. Conclusion: There is no significant impact of long-term VA treatment on the homeostatis of blood sugar among adults measured by the level of fasting blood sugar, 2-hour after-meal blood sugar, and HbA1C.