TY - JOUR
T1 - Association of diffusion weighted magnetic resonance imaging profile and apparent diffusion coefficient value with brain tumor’s histopathology
AU - Wilujeng, Hartati Rusmi Tri
AU - Sensusiati, Anggraini Dwi
AU - Suwandi, M. Yamin Sunaryo
N1 - Publisher Copyright:
© 2020, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Background: Accuracy of preoperative brain tumor’s histopathologic differentiation is very important to determine preoperative staging, intraoperative management and postoperative therapy. Diffusion weighted magnetic resonance imaging is an advanced technique developed as an important method for brain tumor assessment. Objectives: This study aimed to investigate correlation between diffusion weighted imaging (DWI) profile and apparent diffusion coefficient (ADC) value with brain tumor’s histopathology. Methods: This study examined 86 subjects with brain tumors using magnetic resonance imaging and histopathology examination at Dr. Soetomo Teaching Hospital and evaluated DWI profile and ADC maps. The spherical ROI on ADC maps was placed on the solid part of the tumor to measure ADC value. Spearman’s correlation test was conducted to determine correlation between DWI profile and ADC values with histopathological grading and types of brain tumor. Results: There was a significant correlation between DWI profile and ADC values (p = 0.000), as well as DWI and ADC values with histopathological grading and types of brain tumor (p = 0.000). There was an inverse corelation between ADC value and histopathological grading. The higher the ADC value, the lower the brain tumor grade, while lower ADC value resulted in high tumor grade. The average ADC value of grade-1 meningiomas was 1.061±0.257 x 10-3 mm2/sec, pilocytic astrocytoma was 1.301±0.107 x 10-3 mm2/ sec, glioblastoma multiforme was 0.831±0.080 x 10-3 mm2/sec, and medulloblastomas was 0.600±0.078 x 10-3 mm2/sec. Conclusion: Evaluation on DWI profile and ADC value could provide additional information on conventional magnetic resonance imaging examination to determine histopathological grading and types of both intra and extra-axial brain tumors.
AB - Background: Accuracy of preoperative brain tumor’s histopathologic differentiation is very important to determine preoperative staging, intraoperative management and postoperative therapy. Diffusion weighted magnetic resonance imaging is an advanced technique developed as an important method for brain tumor assessment. Objectives: This study aimed to investigate correlation between diffusion weighted imaging (DWI) profile and apparent diffusion coefficient (ADC) value with brain tumor’s histopathology. Methods: This study examined 86 subjects with brain tumors using magnetic resonance imaging and histopathology examination at Dr. Soetomo Teaching Hospital and evaluated DWI profile and ADC maps. The spherical ROI on ADC maps was placed on the solid part of the tumor to measure ADC value. Spearman’s correlation test was conducted to determine correlation between DWI profile and ADC values with histopathological grading and types of brain tumor. Results: There was a significant correlation between DWI profile and ADC values (p = 0.000), as well as DWI and ADC values with histopathological grading and types of brain tumor (p = 0.000). There was an inverse corelation between ADC value and histopathological grading. The higher the ADC value, the lower the brain tumor grade, while lower ADC value resulted in high tumor grade. The average ADC value of grade-1 meningiomas was 1.061±0.257 x 10-3 mm2/sec, pilocytic astrocytoma was 1.301±0.107 x 10-3 mm2/ sec, glioblastoma multiforme was 0.831±0.080 x 10-3 mm2/sec, and medulloblastomas was 0.600±0.078 x 10-3 mm2/sec. Conclusion: Evaluation on DWI profile and ADC value could provide additional information on conventional magnetic resonance imaging examination to determine histopathological grading and types of both intra and extra-axial brain tumors.
KW - ADC value
KW - Brain tumor
KW - Brain tumor histopathology
KW - DWI
UR - http://www.scopus.com/inward/record.url?scp=85087401064&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85087401064
SN - 0973-9122
VL - 14
SP - 1586
EP - 1593
JO - Indian Journal of Forensic Medicine and Toxicology
JF - Indian Journal of Forensic Medicine and Toxicology
IS - 2
ER -