Association between transmission season and degree of severity in guillain-barre syndrome

Guillain-barre syndrome (GBS) is a common cause of acute severe paralysis. This weakness makes people with GBS could not move for a long time, thus disrupting the productivity of the patient. GBS usually occurs after an infectious disease in which the immune response produces cross-reacting antibodies with gangliosides in the neural membrane. Seasonal variations in GBS could be caused by the season of infectious disease that proceeds and it affects the weight of GBS. The study was conducted retrospectively, case-control study, using the hospitalized patient records of GBS patients in Dr. Soetomo Teaching Hospital, Surabaya, which meets the inclusion and exclusion criteria, from January 2013 to October 2016. GBS severity is assessed using the Medical research council (MRC) sum score. The case group was GBS with a severe severity which has a value <36. There were 82 subjects that consist of 41 case groups and 41 control groups. In the case group with the onset of transition symptoms during the transition season, there were 21 people 51.2% more than 15 the control group 36.6%. In contrast, in the control group, the onset symptom was not the transition season, 26 people 63.4% than the case group of 20 people 48.8%. However, this difference was not statistically significant with p = 0.182 and research objectives (RO) 1.82 (CI 95% 0.753−4.399). There was no correlation between the transmission season and the severity of GBS.