Association Between Systemic Inflammation Immun Index and In-stent Restenosis, Stent Thrombosis, and No Flow Phenomenon After Stent Implantation Was Examined in Systematic Review and Meta-analysis

Introduction: The systemic inflammatory index (SII) is a potential predictor for cardiovascular diseases. High SII may reflect a greater inflammatory response, which may worsen neointimal hyperplasia and increase the risk of restenosis. Materials and methods: This study employed a systematic review and meta-analysis design, comply the PRISMA 2020 guidelines. A search was conducted on several global scientific databases, such as PubMed, Science Direct, Google Scholar, Springer, and Proquest. Results: This study analyzed 10 studies with the total of 5.237 patients were included. The results revealed a significant association between a high SII value and intra-stent restenosis (OR= 4.94, 95% CI 4.23 - 5.77; p < 0.001). stent thrombosis (OR= 3.82, 95% CI 2.25 - 6.48; p < 0.001) no-reflow phenomenon (OR= 4.59, 95% CI 3.83 - 5.51; p < 0.001). Conclusion: There is a robust correlation between the SII value and intra-stent restenosis, stent thrombosis, and the no-reflow phenomenon incidents, particularly at elevated SII levels.