Abstract

Polymorphisms of the leptin receptor gene (LEPR) are known to occur at several sites of this gene and are thought to play a role in leptin resistance which causes obesity. The most extensively researched single nucleotide polymorphism is found in codon 223, which results in the conversion of glutamine (CAG) to arginine (CGG) by changing adenine (A) to guanine (G). However, its relationship with anthropometric and metabolic parameters of obesity is still unclear. The genetic variant on the LEPR may alter the receptor’s structure and function which affects fat accumulation in obesity. However, it might provide diverse outcomes among individuals of different ages, sexes, and ethnicities. This review aims to determine the association between Gln223Arg LEPR polymorphisms and obesity in several populations in the world, and the insight into oral health, especially the inflammatory underlying oral diseases. As the result of this review article, the relationship between LEPR polymorphisms and obesity including its metabolic alteration varies between populations, possibly due to gene-to-gene communication or gene interaction with the environment.

Original languageEnglish
Pages (from-to)156-165
Number of pages10
JournalMalaysian Journal of Medicine and Health Sciences
Volume20
DOIs
Publication statusPublished - Dec 2024

Keywords

  • Gene polymorphism
  • LEPR
  • Leptin receptor
  • Obesity
  • Oral health

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