TY - JOUR
T1 - Association Between Leptin Receptor Gene (LEPR) Polymorphism and Obesity
T2 - A Review
AU - Yuliawati, Tri Hartini
AU - Tirthaningsih, Ni Wajan
AU - Ugrasena, I. Dewa Gede
AU - Soesilawati, Pratiwi
AU - Notopuro, Harianto
N1 - Publisher Copyright:
© 2024 Universiti Putra Malaysia Press. All rights reserved.
PY - 2024/12
Y1 - 2024/12
N2 - Polymorphisms of the leptin receptor gene (LEPR) are known to occur at several sites of this gene and are thought to play a role in leptin resistance which causes obesity. The most extensively researched single nucleotide polymorphism is found in codon 223, which results in the conversion of glutamine (CAG) to arginine (CGG) by changing adenine (A) to guanine (G). However, its relationship with anthropometric and metabolic parameters of obesity is still unclear. The genetic variant on the LEPR may alter the receptor’s structure and function which affects fat accumulation in obesity. However, it might provide diverse outcomes among individuals of different ages, sexes, and ethnicities. This review aims to determine the association between Gln223Arg LEPR polymorphisms and obesity in several populations in the world, and the insight into oral health, especially the inflammatory underlying oral diseases. As the result of this review article, the relationship between LEPR polymorphisms and obesity including its metabolic alteration varies between populations, possibly due to gene-to-gene communication or gene interaction with the environment.
AB - Polymorphisms of the leptin receptor gene (LEPR) are known to occur at several sites of this gene and are thought to play a role in leptin resistance which causes obesity. The most extensively researched single nucleotide polymorphism is found in codon 223, which results in the conversion of glutamine (CAG) to arginine (CGG) by changing adenine (A) to guanine (G). However, its relationship with anthropometric and metabolic parameters of obesity is still unclear. The genetic variant on the LEPR may alter the receptor’s structure and function which affects fat accumulation in obesity. However, it might provide diverse outcomes among individuals of different ages, sexes, and ethnicities. This review aims to determine the association between Gln223Arg LEPR polymorphisms and obesity in several populations in the world, and the insight into oral health, especially the inflammatory underlying oral diseases. As the result of this review article, the relationship between LEPR polymorphisms and obesity including its metabolic alteration varies between populations, possibly due to gene-to-gene communication or gene interaction with the environment.
KW - Gene polymorphism
KW - LEPR
KW - Leptin receptor
KW - Obesity
KW - Oral health
UR - http://www.scopus.com/inward/record.url?scp=85214328279&partnerID=8YFLogxK
U2 - 10.47836/mjmhs.20.s12.22
DO - 10.47836/mjmhs.20.s12.22
M3 - Review article
AN - SCOPUS:85214328279
SN - 1675-8544
VL - 20
SP - 156
EP - 165
JO - Malaysian Journal of Medicine and Health Sciences
JF - Malaysian Journal of Medicine and Health Sciences
ER -