Assessment of Cisplatin-Induced Kidney Injury Through Histopathological Changes in Mouse Models

The purpose of the study is to assesst cisplatin-induced kidney injury on cancer therapy through histopathological changes in mouse models. Group 1 served as the control group and received normal saline intraperitoneally (25 ml/kg). Group 2 was injected intraperitoneally cisplatin in a single dose of 25 mg/kg. Seventy two hours after cisplatin injection, all mice of both groups were sacrificed to exam the kidneys histopathological changes. There was no kidney injury histologically showed normal architecture of the glomerulus and tubules in control mice, while in cisplatin injected mice group, kidney injury histologically first marked with mononuclear cell infiltration, glomerular congestion, tubular necrosis and hyaline casts in the tubular lumen.