Association between bleeding volume with heme oxygenase-1 and malondialdehyde levels in patients of acute intracerebral hemorrhage

Background: Oxidative stress plays an important role in secondary brain damage after a stroke of intracerebral hemorrhage because it causes permanent damage to grey matter, white matter taken by brain blood barrier disorders, and brain edema with brain cells. This study aimed to determine the correlation between bleeding volume and heme oxygenase-1 (HO-1) and malondialdehyde (MDA) levels in stroke patients with acute intracerebral hemorrhage at Dr. Soetomo Hospital, Surabaya. Methods: This was a cross-sectional analytic study with 34 study subjects who met the inclusion and exclusion criteria from August 2019 to November 2019. Subjects were measured for bleeding volume and blood collection for examination of HO-1 levels and MDA levels at hospital admission in stroke patients with acute intracerebral hemorrhage. Results: The mean bleeding volume in this study was 15.34±10.26 mL, the mean level of HO-1 was 55.51±138.06 ng/mL, and the mean level of MDA was 1066.03±907.97 ng/mL. Statistical analysis did not obtain any significant correlation between bleeding volume and HO-1 level (p= 0.605). However, there was a significant correlation statistically between bleeding volume and MDA level (r= 0.509; p= 0.002). Conclusion: There was a correlation between bleeding volume level and the level of MDA in stroke patients with acute intracerebral hemorrhage, although there was no significant correlation between bleeding volume and HO-1 levels.