TY - JOUR
T1 - Epigenetic Approach on Colorectal Cancer Systemic Therapy
T2 - Promising yet a Long Way to Go
AU - Rezkitha, Yudith Annisa Ayu
AU - Savitri, Camilia Metadea Aji
AU - Lusida, Maria Inge
AU - Bintoro, Siprianus Ugroseno Yudho
AU - Rahmawati, Lita Diah
AU - I’tishom, Reny
AU - Miftahussurur, Muhammad
N1 - Publisher Copyright:
© 2022 Academia Nacional de Medicina. All rights reserved.
PY - 2022/7
Y1 - 2022/7
N2 - Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.
AB - Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.
UR - http://www.scopus.com/inward/record.url?scp=85135110936&partnerID=8YFLogxK
U2 - 10.47307/GMC.2022.130.2.14
DO - 10.47307/GMC.2022.130.2.14
M3 - Article
AN - SCOPUS:85135110936
SN - 0367-4762
VL - 130
SP - 357
EP - 370
JO - Gaceta Medica de Caracas
JF - Gaceta Medica de Caracas
IS - 2
ER -
