Aproximación epigenética sobre la terapia sistémica del cáncer colorrectal: prometedor pero un largo camino por recorrer

Translated title of the contribution: Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go

Yudith Annisa Ayu Rezkitha, Camilia Metadea Aji Savitri, Maria Inge Lusida, Siprianus Ugroseno Yudho Bintoro, Lita Diah Rahmawati, Reny I’tishom, Muhammad Miftahussurur

Research output: Contribution to journalArticlepeer-review

Abstract

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.

Translated title of the contributionEpigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go
Original languageSpanish
Pages (from-to)357-370
Number of pages14
JournalGaceta Medica de Caracas
Volume130
Issue number2
DOIs
Publication statusPublished - Jul 2022

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