Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.

Original languageEnglish
Pages (from-to)357-370
Number of pages14
JournalGaceta Medica de Caracas
Issue number2
Publication statusPublished - Jul 2022


Dive into the research topics of 'Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go'. Together they form a unique fingerprint.

Cite this