Application of purple leaf extract (Graptophyllum pictum) in wound healing process of collagen density

Muhammad Ramadhan Brahmantyo, Intan Nirwana, Dan Devi Rianti

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Purple leaves are derived from the Graptophyllum pictum plant, the Acanthacea family contains: flavonoids, saponins, and tannins. Purple leaf extract has anti-inflammatory and analgesic effects. Purpose: This study observed an increase in the density of collagen in wounds in wistar rats. Methods: The research subjects were 24 adult and healthy Wistar (Rattus norvegicus) mice, aged 3 months, with a body weight of 200 grams, which were divided into 6 groups of 4 rats each. The making of purple leaf extract is as follows, purple leaf powder weighed as much as 500 grams, then moistened with 96% ethanol as much as 500 ml. Research data were analyzed using the Kruskall Wallis and Mann Whitney tests. Results: Statistical data analysis using the Kruskall Wallis test showed significant differences in collagen density (P<0.005). Conclusion: Giving a 15% purple leaf extract gel increases collagen density.

Original languageEnglish
Pages (from-to)1541-1545
Number of pages5
JournalInternational Journal of Pharmaceutical Research
Issue number4
Publication statusPublished - 1 Oct 2020


  • Collagen
  • Incision
  • Purple leaf (Graptophyllum pictum)
  • Wound healing


Dive into the research topics of 'Application of purple leaf extract (Graptophyllum pictum) in wound healing process of collagen density'. Together they form a unique fingerprint.

Cite this