TY - JOUR
T1 - Antioxidant potency of Okra (Abelmoschus esculentus moench) pods extract on SOD level and tissue glucose tolerance in diabetic mice
AU - Husen, Saikhu A.
AU - Wahyuningsih, Sri P.A.
AU - Ansori, Arif N.M.
AU - Hayaza, Suhailah
AU - Susilo, Raden J.K.
AU - Winarni, Dwi
AU - Punnapayak, Hunsa
AU - Darmanto, Win
N1 - Funding Information:
The support of this study was granted by The Ministry of Research, Technology, and Higher Education of the Republic of Indonesia. We are also delighted to deliver our gratitude to the PMDSU Scholarship (Batch III) that was being awarded to Arif Nur Muhammad Ansori, Raden Joko Kuncoroningrat Susilo, and Suhailah Hayaza.
Publisher Copyright:
© RJPT All right reserved.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The purpose of this study was to determine the effect of various fractions of okra pods extract (VOPE) on superoxide dismutase (SOD) level and tissue glucose tolerance in the streptozotocin (STZ) induced diabetic mice. This study was using 35 male Balb/c strain mice. The samples were divided into seven groups, namely KN (normal control), KD (diabetic control), KA (acarbose control), EK (crude extract), NP (non-polar), SP (semi-polar), and EP (polar). VOPE and acarbose suspension were administered orally for 14 days in the STZ-induced diabetic mice. Intraperitoneal injection of multiple low-dose STZ (30mg/kg body weight) induced diabetes daily for five consecutive days. On the 15th day, the mice were terminated. Data of SOD level and tissue glucose tolerance were analyzed by ANOVA, at α = 0.05. This study concluded that the administration of VOPE could increase SOD level and tissue glucose tolerance in the STZ-induced diabetic mice. In conclusion, VOPE is a promising antioxidant agent due to its antihyperglycemic properties.
AB - The purpose of this study was to determine the effect of various fractions of okra pods extract (VOPE) on superoxide dismutase (SOD) level and tissue glucose tolerance in the streptozotocin (STZ) induced diabetic mice. This study was using 35 male Balb/c strain mice. The samples were divided into seven groups, namely KN (normal control), KD (diabetic control), KA (acarbose control), EK (crude extract), NP (non-polar), SP (semi-polar), and EP (polar). VOPE and acarbose suspension were administered orally for 14 days in the STZ-induced diabetic mice. Intraperitoneal injection of multiple low-dose STZ (30mg/kg body weight) induced diabetes daily for five consecutive days. On the 15th day, the mice were terminated. Data of SOD level and tissue glucose tolerance were analyzed by ANOVA, at α = 0.05. This study concluded that the administration of VOPE could increase SOD level and tissue glucose tolerance in the STZ-induced diabetic mice. In conclusion, VOPE is a promising antioxidant agent due to its antihyperglycemic properties.
KW - Abelmoschus esculentus Moench
KW - Diabetic Mice
KW - SOD Level
KW - Tissue Glucose Tolerance
UR - http://www.scopus.com/inward/record.url?scp=85078401572&partnerID=8YFLogxK
U2 - 10.5958/0974-360X.2019.00983.1
DO - 10.5958/0974-360X.2019.00983.1
M3 - Article
AN - SCOPUS:85078401572
SN - 0974-3618
VL - 12
SP - 5683
EP - 5688
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 12
ER -
