TY - JOUR
T1 - Antioxidant effects of Sarang Semut (Myrmecodia pendans) on the apoptosis of spermatogenic cells of rats exposed to plumbum
AU - Lamondo, Djuna
AU - Soegianto, Agoes
AU - Abadi, Agus
AU - Keman, Soedjajadi
PY - 2014
Y1 - 2014
N2 - Active compounds in Sarang Semut are flavonoids, tannins, polyphenols, and tocopherols which serve as primary antioxidants in the body. The existence of these antioxidants enables Sarang Semut to be used to address the free radicals induced by plumbum (Pb). The objective of this study was to analyze antioxidant effects of Sarang Semut on the number of apoptosis spermatogenic cells, malondialdehyde (MDA) levels and superoxide dismutase (SOD) of serum. Compared to the control group, the number of apoptosis of spermatogenic cells and the MDA level of serum of the group exposed to Pb showed a significant increase (P < 0.05), and the level of SOD of serum showed a significant decrease (P < 0.05). After the provision of the extract and fraction of Sarang Semut, the exposed group showed a significant decrease (P < 0.05) in the number of spermatogenic cells and MDA level of serum, and a significant increase (P < 0.05) in the level of SOD. Antioxidants of Sarang Semut can decrease the number of apoptosis spermatogenic cells and the MDA level of serum, and increase the level of SOD serum of rats exposed to Pb.
AB - Active compounds in Sarang Semut are flavonoids, tannins, polyphenols, and tocopherols which serve as primary antioxidants in the body. The existence of these antioxidants enables Sarang Semut to be used to address the free radicals induced by plumbum (Pb). The objective of this study was to analyze antioxidant effects of Sarang Semut on the number of apoptosis spermatogenic cells, malondialdehyde (MDA) levels and superoxide dismutase (SOD) of serum. Compared to the control group, the number of apoptosis of spermatogenic cells and the MDA level of serum of the group exposed to Pb showed a significant increase (P < 0.05), and the level of SOD of serum showed a significant decrease (P < 0.05). After the provision of the extract and fraction of Sarang Semut, the exposed group showed a significant decrease (P < 0.05) in the number of spermatogenic cells and MDA level of serum, and a significant increase (P < 0.05) in the level of SOD. Antioxidants of Sarang Semut can decrease the number of apoptosis spermatogenic cells and the MDA level of serum, and increase the level of SOD serum of rats exposed to Pb.
KW - Apoptosis
KW - Lead acetate
KW - Sarang semut
KW - Spermatogenic cells
UR - http://www.scopus.com/inward/record.url?scp=84904654401&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84904654401
SN - 0975-8585
VL - 5
SP - 282
EP - 294
JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences
JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences
IS - 4
ER -