Antioxidant and antiviral potency of Begonia medicinalis fractions

Muhammad Sulaiman Zubair, Siti Qamariyah Khairunisa, Evi Sulastri, Ihwan, Agustinus Widodo, Nasronudin, Ramadanil Pitopang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


This study aims to evaluate the antioxidant and antiviral potency of n-hexane, ethyl acetate and, water fractions of Begonia medicinalis Ardi & D.C.Thomas as well as to identify the chemical constituents. Assays for antioxidant and antiviral activity (HIV-1) were carried out on MT-4 cells infected with HIV using the DPPH method and the determination of the cytopathic effect. Meanwhile, GC-MS was used to identify the chemical compounds. The determination of antioxidants showed that all fractions possessed potent activity with the IC50 ranging from 2.61 to 8.26 μg/mL. From the antiviral activity of MT-4 cells infected by HIV, the n-hexane fraction of B. medicinalis showed the most potency with the IC50 of 0.04 ± 0.05 μg/mL. It has less cytotoxicity (11.08 ± 4.60 μg/mL) affording the high selectivity index of 238.80. Furthermore, GC-MS analysis of n-hexane fraction found the major compound of carboxylic acid derivate with the area percentage of 76.4% and the presence of phenolic compounds (8.38%). Meanwhile, in water fraction, terpenoids were found in a higher concentration (10.05%) than others. Therefore, this study supports the application of B. medicinalis as a herbal medicine for antioxidant and antiviral.

Original languageEnglish
Pages (from-to)845-851
Number of pages7
JournalJournal of Basic and Clinical Physiology and Pharmacology
Issue number4
Publication statusPublished - 1 Jul 2021


  • Begonia medicinalis
  • GC-MS
  • HIV-1
  • antioxidant
  • antiviral


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