TY - JOUR
T1 - Antigen Candidates for Atherosclerosis Vaccine Development
AU - Putri, D. K.S.C.
AU - Al-Farabi, M. J.
AU - Suryawan, I. G.R.
N1 - Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2020/2/24
Y1 - 2020/2/24
N2 - Atherosclerosis is a major cardiovascular issue in the world. Atherosclerosis has long been theorized to be originated from foam cells that build up due to the chronic inflammatory process of cholesterol deposition in the walls of blood vessels and the uptake of oxidized LDL (OxLDL) and phosphorylcholine. Until now, the treatment for atherosclerosis has been focusing on drugs that inhibit the progression of atherosclerotic plaques. Recent findings show that proper regulation of immune cells, both adaptive and innate, has been shown to have a relationship with the prevention of atherosclerotic lesions. The future of vaccination as prevention for atherosclerosis holds great potential, considering studies are abundant in proving the atheroprotective effects of the immunization with several types of antigens. In this literature review, we will discuss the types of antigens which hold promising potentials for atherosclerosis vaccine development and its future challenges.
AB - Atherosclerosis is a major cardiovascular issue in the world. Atherosclerosis has long been theorized to be originated from foam cells that build up due to the chronic inflammatory process of cholesterol deposition in the walls of blood vessels and the uptake of oxidized LDL (OxLDL) and phosphorylcholine. Until now, the treatment for atherosclerosis has been focusing on drugs that inhibit the progression of atherosclerotic plaques. Recent findings show that proper regulation of immune cells, both adaptive and innate, has been shown to have a relationship with the prevention of atherosclerotic lesions. The future of vaccination as prevention for atherosclerosis holds great potential, considering studies are abundant in proving the atheroprotective effects of the immunization with several types of antigens. In this literature review, we will discuss the types of antigens which hold promising potentials for atherosclerosis vaccine development and its future challenges.
UR - http://www.scopus.com/inward/record.url?scp=85081174472&partnerID=8YFLogxK
U2 - 10.1088/1755-1315/441/1/012164
DO - 10.1088/1755-1315/441/1/012164
M3 - Conference article
AN - SCOPUS:85081174472
SN - 1755-1307
VL - 441
JO - IOP Conference Series: Earth and Environmental Science
JF - IOP Conference Series: Earth and Environmental Science
IS - 1
M1 - 012164
T2 - 2nd International Conference on Fisheries and Marine Science, InCoFiMS 2019
Y2 - 26 September 2019
ER -
