TY - JOUR
T1 - Antidiabetic activity of papaya leaf extract (Carica Papaya L.) isolated with maceration method in alloxan-induces diabetic mice
AU - Solikhah, Tridiganita Intan
AU - Setiawan, Boedi
AU - Ismukada, Dilian Ramdana
N1 - Publisher Copyright:
© 2020 EManuscript Technologies. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Introduction: Diabetes mellitus is a metabolic disorder disease that is often found in the world. Treatment with natural products can be an effective alternative in treating diabetes mellitus. Papaya (Carica papaya) has many pharmacological activities that have potential as an antidiabetic. Objective: This study aimed to determine the content of compounds in the papaya leaf ethanol extract and the effect of papaya leaf ethanol extract (Carica papaya L.) on the blood sugar level of diabetic mice induced by alloxan. Methods: The mice were adapted for 7 days and were induced on the 8 days with 180 mg/kg alloxan intraperitoneally. Papaya leaf ethanol extract (Carica papaya L.) was given for 14 days at a dose of 250, 500, and 1000 mg/kg body weight and was compared to distilled water and alloxan only as negative control and glibenclamide at a dose of 2 mg/kg body weight as the positive control. Blood samples were collected on day 1, 7, and 14 to evaluate blood glucose levels before and after treatment. Results: The compounds contained in the ethanol extract of papaya leaf include alkaloids, flavonoids, triterpenoids, tannins, and saponins. The administration of papaya leaf ethanol extract with 3 doses and glibenclamide at a dose of 2 mg/kg body weight could reduce blood glucose levels in diabetic Wistar mice induced by alloxan. The administration at a dose of 1000 mg/kg body weight of papaya leaf ethanol extract is more effective in reducing blood glucose levels in diabetic Wistar mice compared to 2 mg/kg body weight of glibenclamide. Conclusion: Induction of Carica papaya leaf extracts decreased blood sugar levels but cannot effectively increased the body weight in diabetic mice.
AB - Introduction: Diabetes mellitus is a metabolic disorder disease that is often found in the world. Treatment with natural products can be an effective alternative in treating diabetes mellitus. Papaya (Carica papaya) has many pharmacological activities that have potential as an antidiabetic. Objective: This study aimed to determine the content of compounds in the papaya leaf ethanol extract and the effect of papaya leaf ethanol extract (Carica papaya L.) on the blood sugar level of diabetic mice induced by alloxan. Methods: The mice were adapted for 7 days and were induced on the 8 days with 180 mg/kg alloxan intraperitoneally. Papaya leaf ethanol extract (Carica papaya L.) was given for 14 days at a dose of 250, 500, and 1000 mg/kg body weight and was compared to distilled water and alloxan only as negative control and glibenclamide at a dose of 2 mg/kg body weight as the positive control. Blood samples were collected on day 1, 7, and 14 to evaluate blood glucose levels before and after treatment. Results: The compounds contained in the ethanol extract of papaya leaf include alkaloids, flavonoids, triterpenoids, tannins, and saponins. The administration of papaya leaf ethanol extract with 3 doses and glibenclamide at a dose of 2 mg/kg body weight could reduce blood glucose levels in diabetic Wistar mice induced by alloxan. The administration at a dose of 1000 mg/kg body weight of papaya leaf ethanol extract is more effective in reducing blood glucose levels in diabetic Wistar mice compared to 2 mg/kg body weight of glibenclamide. Conclusion: Induction of Carica papaya leaf extracts decreased blood sugar levels but cannot effectively increased the body weight in diabetic mice.
KW - Alloxan
KW - Antidiabetic
KW - Carica papaya L
KW - Ethanol Extract
KW - Wistar Mice
UR - http://www.scopus.com/inward/record.url?scp=85094635070&partnerID=8YFLogxK
U2 - 10.31838/srp.2020.9.109
DO - 10.31838/srp.2020.9.109
M3 - Article
AN - SCOPUS:85094635070
SN - 0975-8453
VL - 11
SP - 774
EP - 778
JO - Systematic Reviews in Pharmacy
JF - Systematic Reviews in Pharmacy
IS - 9
ER -