Diabetes mellitus (DM) is considered to be one of the most common chronic diseases worldwide. Medicinal plants from Indonesia may lead to the discovery of the novel drugs. Mangosteen or Garcinia mangostana L. is a native tropical fruit from Southeast Asia and known to contain bioactive compounds which have a particular function as an antioxidant. This study was performed to review the phytochemical and anti-diabetic compounds of the whole plant of mangosteen. The review was carried out by analysing peer-reviewed and indexed journals of Garcinia mangostana L. from Google Scholar, PubMed, Scopus, and so on. Interestingly, the main xanthone derivative are alpha-mangostin and gamma-mangostin, these compounds have a variety of pharmacological activities such as antidiabetic. This review showed the potential pharmacological benefits of mangosteen in preventing and treating type-2 DM. In sum, mangosteen exhibits it as a valuable plant and establish it as a candidate for future drug development of DM.

Original languageEnglish
Pages (from-to)3173-3177
Number of pages5
JournalBiochemical and Cellular Archives
Publication statusPublished - 2020


  • Antidiabetes
  • Diabetes mellitus
  • Garcinia mangostana L.
  • Medicinal plant


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