Anticancer Effect of Naringin on Human Colon Cancer (WiDr Cells): In Vitro Study

Amaq Fadholly, Arif N.M. Ansori, Budi Utomo

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Naringin, a bioflavonoid naturally found in citrus species, has been exert as promising anticancer activities. However, naringin mechanism as anticancer still remain enigmatic. This study, WiDr cell lines as human colon cancer cell in vitro were used to evaluate anticancer effect of naringin. Naringin (10, 20, 40, 60, 80µg/mL) treated on WiDr cells to evaluate IC50 value by MTT assay, then continued with analyzed caspase-3 expressions (IC50, 2IC50) as apopotosis marker. This study reported that naringin inhibit the growth of WiDr cell with IC50 value is 63.14µg/mL. The caspase-3 expressions on 2IC50 is higher (74.66%) than IC50 (56.66%). These results indicate that naringin has properties of inhibting cell growth and inducing caspase-3 expressions on WiDr cells. It is a potential compound to be developed as a chemopreventive agent for colon cancer.

Original languageEnglish
Pages (from-to)885-888
Number of pages4
JournalResearch Journal of Pharmacy and Technology
Issue number2
Publication statusPublished - Feb 2022


  • Apoptosis
  • Caspase-3
  • Colon cancer
  • Naringin


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