Anticancer activity of Centella asiatica leaves extract in benzo(a)pyrene-induced mice

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13 Citations (Scopus)

Abstract

Utilization of Centella asiatica leaves extract became an alternative to determine its activities. Centella asiatica contained of asiatic acid, madecassic acid, glicosides, asiaticoside, madecassoside, and some other compound. Centella asiatica has the potential as anti-cancer medicine. This research aims to understand the effects of Centella asiatica leaves extract on decreasing the number of benzo(a)pyrene induced lung tumor nodules. Then, determine the lung histopathological features of induced mice. This research used 30 of one day old baby mice which divided into six groups. Positive control (group I) was induced with benzo(a)pyrene of 0.2 μmol on day-1; 0.4 μmol on day-7 and 0.8 μmol on day-15 without any extracts. Group II was treated with Tamoxifen and induced with benzo(a)pirene. Negative control (group III) received only DMSO solvent and groups III, IV, V received 250, 500 and 750 mg/kg bw of Centella asiatica leaves extract on day-25. The significant difference (p<0.05) of Centella asiatica leaves extract on the number of benzo(a)pyrene which induced by lung tumor nodules. The treatment with 250, 500 and 750 mg/kg bb doses of extract resulted a non significant different (p<0.05) means number of lung tumor nodules. Microscopic examination of lung histopathological features showed a decrease on tumor foci in bronchus, alveolar septum and also inhibit bronchial epithelial cell hyperplasia. Ethanolic extract of Centella asiatica could reduce the number of tumor nodules and inhibit the development of benzo(a)pyrene.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalInternational Journal of Pharmacognosy and Phytochemical Research
Volume8
Issue number1
Publication statusPublished - Jan 2016

Keywords

  • Benzo(a)pyrene
  • Centella asiatica
  • Hyperplasia
  • Lung cancer
  • Tumor nodule

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