TY - JOUR
T1 - Antibacterial Effectiveness of Chitosan Solution on Streptococcus Mutans
AU - Wahjuningrum, Dian Agustin
AU - Setyabudi,
AU - Hadinata, Daniel
AU - Amalia, Ilona Talitha
AU - Roi'Fa, Rizki Annisa
AU - Juniarti, Devi Eka
N1 - Funding Information:
This research is supported by Ministry of Research and Technology Indonesia and Dental Research Centre of Faculty of Dental Medicine, Universitas Airlangga Surabaya.
Publisher Copyright:
© Copyright Wahjuningrum. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided thatthe original author and source are credited.
PY - 2022/7
Y1 - 2022/7
N2 - Dental caries is a localized destruction on teeth by organic acid produced by carbohydrate fermentation of cariogenic bacteria. Streptococcus mutans is a Gram-positive bacterium, a facultative anaerobe species often found in human oral cavity and is a significant contributor to dental caries. Chitosan is the collective name of a group of partially or fully deacetylated chitin. Because of its unique biological properties, including biodegradability and nontoxicity, a lot of applications have been found for chitosan, on its own or combined with other polymers. Chitosan has a wide spectrum of activity and high killing rate against Gram positive and Gram-negative bacteria, while having low toxicity against mammal cell. In this research a Kirby-Bauer test is done on Streptococcus mutans using 1%, 1.5%, and 2% chitosan solution as treatment group and aquades as control group. Average of each group is calculated and significancy is determined using statistical calculation. The resulting data is analyzed using Kruskal-Wallis and Post-hoc Tukey HSD and is shown there to be a significant difference between each treatment groups. The biggest zone of inhibition is seen on the 2% chitosan solution group. 2% chitosan solution has higher antibacterial effectiveness on Streptococcus mutans than 1% and 1.5% chitosan solution.
AB - Dental caries is a localized destruction on teeth by organic acid produced by carbohydrate fermentation of cariogenic bacteria. Streptococcus mutans is a Gram-positive bacterium, a facultative anaerobe species often found in human oral cavity and is a significant contributor to dental caries. Chitosan is the collective name of a group of partially or fully deacetylated chitin. Because of its unique biological properties, including biodegradability and nontoxicity, a lot of applications have been found for chitosan, on its own or combined with other polymers. Chitosan has a wide spectrum of activity and high killing rate against Gram positive and Gram-negative bacteria, while having low toxicity against mammal cell. In this research a Kirby-Bauer test is done on Streptococcus mutans using 1%, 1.5%, and 2% chitosan solution as treatment group and aquades as control group. Average of each group is calculated and significancy is determined using statistical calculation. The resulting data is analyzed using Kruskal-Wallis and Post-hoc Tukey HSD and is shown there to be a significant difference between each treatment groups. The biggest zone of inhibition is seen on the 2% chitosan solution group. 2% chitosan solution has higher antibacterial effectiveness on Streptococcus mutans than 1% and 1.5% chitosan solution.
KW - antibacterial
KW - chitosan
KW - concentration
KW - infectious disease
KW - Streptococcus mutans
UR - http://www.scopus.com/inward/record.url?scp=85143386458&partnerID=8YFLogxK
U2 - 10.11113/mjfas.v18n4.2519
DO - 10.11113/mjfas.v18n4.2519
M3 - Article
AN - SCOPUS:85143386458
SN - 2289-599X
VL - 18
SP - 483
EP - 488
JO - Malaysian Journal of Fundamental and Applied Sciences
JF - Malaysian Journal of Fundamental and Applied Sciences
IS - 4
ER -