Antiangiogenesis activity of centella asiatica on the macrophage number and matrix metalloproteinase-9 in blood vessels of chorioallantois membrane induced by basic fibroblast growth factor

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Abstract

This study aimed to examine the potential of aqueous extract of Centella asiatica on the macrophage number and matrix metalloproteinase- 9 (MMP-9) in blood vessels of chorioallantois membrane induced by basic Fibroblast Growth Factor (bFGF). This study used 20 embryonated chicken eggs (ECE) which were divided into five groups i.e. positive control (C+) given 60 ng of bFGF; negative control (C-) given DMSO 2%; treatment groups (T1; T2; T3) given 60 ng of bFGF and Centella asiatica extract (75; 90; 110) μg. It was concluded that Centella asiatica at a dose of 110 μg decreased the macrophage number and the expression of MMP-9.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalIndian Veterinary Journal
Volume97
Issue number2
Publication statusPublished - 2020

Keywords

  • Centella asiatica
  • Chorioallantois membrane
  • MMP-9
  • Macrophage

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