TY - JOUR
T1 - Anti phenolic glycolipid i (PGLI) of salivary IgA/IgM from Mycobacterium leprosy for early detection of subclinical leprosy
AU - Mayangsari, Maria Andisa
AU - Wardhana, Muhammad Yoga
AU - Ramadhani, Nastiti Faradilla
AU - Nugraha, Alexander Patera
AU - Ridwan, Rini Devijanti
N1 - Publisher Copyright:
© 2020, Connect Journal.
PY - 2020
Y1 - 2020
N2 - Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium leprae. Indonesia is one of the countries with the highest leprosy, 3rd after India and Brazil. In 2013, Indonesia has 16.856 of new leprosy cases. In diagnosing leprosy, physical clinical examination not always able to detect the early phase of the disease. Therefore, we need a diagnostic tool that can detect infection with Mycobacterium leprae early so that treatment can be performed optimally. Saliva contains a lot of protein and nucleic acid molecules that reflect physiological and pathological status. Through saliva, anti Phenolic glycolipid 1 (anti-PGL1) dan be examined which is a specific antibody against PGL1 M. leprae found in the cell wall. Anti-PGL1is produced as a form of immune response against M. leprae. Individuals with a positive anti-PGL1 shown to have six times greater risk of developing leprosy. Serological examination by ELISA for detection of anti-PGL1 is potential to become a tool for early detection of subclinical leprosy (presence of bacilli), these results are useful to monitor and prevent the possibility of leprosy. Journal and other literature study searched with specific keywords. The result shows salivary anti-PGL1 is representative for M. leprae infection. Examination of anti-PGL1 in saliva can unlock the potential diagnosis of safe, sensitive and non-invasive to leprosy especially in endemic areas.
AB - Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium leprae. Indonesia is one of the countries with the highest leprosy, 3rd after India and Brazil. In 2013, Indonesia has 16.856 of new leprosy cases. In diagnosing leprosy, physical clinical examination not always able to detect the early phase of the disease. Therefore, we need a diagnostic tool that can detect infection with Mycobacterium leprae early so that treatment can be performed optimally. Saliva contains a lot of protein and nucleic acid molecules that reflect physiological and pathological status. Through saliva, anti Phenolic glycolipid 1 (anti-PGL1) dan be examined which is a specific antibody against PGL1 M. leprae found in the cell wall. Anti-PGL1is produced as a form of immune response against M. leprae. Individuals with a positive anti-PGL1 shown to have six times greater risk of developing leprosy. Serological examination by ELISA for detection of anti-PGL1 is potential to become a tool for early detection of subclinical leprosy (presence of bacilli), these results are useful to monitor and prevent the possibility of leprosy. Journal and other literature study searched with specific keywords. The result shows salivary anti-PGL1 is representative for M. leprae infection. Examination of anti-PGL1 in saliva can unlock the potential diagnosis of safe, sensitive and non-invasive to leprosy especially in endemic areas.
KW - Anti-PGL1
KW - Leprosy
KW - Mycobacterium leprae
KW - Neglected disease
KW - Salivary IgA/IgM
UR - http://www.scopus.com/inward/record.url?scp=85091202430&partnerID=8YFLogxK
U2 - 10.35124/bca.2020.20.S1.2963
DO - 10.35124/bca.2020.20.S1.2963
M3 - Article
AN - SCOPUS:85091202430
SN - 0972-5075
VL - 20
SP - 2963
EP - 2969
JO - Biochemical and Cellular Archives
JF - Biochemical and Cellular Archives
ER -