TY - JOUR
T1 - Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla
AU - Fadaeinasab, Mehran
AU - Taha, Hairin
AU - Fauzi, Putri Narrima Mohd
AU - Ali, Hapipah Mohd
AU - Widyawaruyanti, Aty
N1 - Publisher Copyright:
© 2015 SAGE Publications Inc.
PY - 2015
Y1 - 2015
N2 - Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 μM, 0.05 μM, 1.18 μM, 3.11 μM, 0.65 μM, 0.26 μM, and 1.38 μM for cycleanine, 10-demethylxylopinine, reticuline, laurotetanine, bicuculine, α-hydrastine and anolobine, respectively, which are comparable with the reference standard, chloroquine. 10-Demethylxylopinine was found to be the most active of these compounds.
AB - Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 μM, 0.05 μM, 1.18 μM, 3.11 μM, 0.65 μM, 0.26 μM, and 1.38 μM for cycleanine, 10-demethylxylopinine, reticuline, laurotetanine, bicuculine, α-hydrastine and anolobine, respectively, which are comparable with the reference standard, chloroquine. 10-Demethylxylopinine was found to be the most active of these compounds.
KW - Actinodaphne macrophylla
KW - Antiplasmodial activity
KW - Isoquinoline alkaloids
KW - Lauraceae
KW - Plasmodium falciparum 3D7
UR - http://www.scopus.com/inward/record.url?scp=84954579702&partnerID=8YFLogxK
U2 - 10.1177/1934578X1501000913
DO - 10.1177/1934578X1501000913
M3 - Article
C2 - 26594753
AN - SCOPUS:84954579702
SN - 1934-578X
VL - 10
JO - Natural Product Communications
JF - Natural Product Communications
IS - 9
ER -