Analysis of the mean gray scale and the mandibular thickness (Micro-CT) to mandibular bone density in synthetic scaffold-hadmsc

Introduction. The concept of biofactor transplantation in porous and degradable materials as scaffolds is a place for regenerating new cell and bone tissue growth in the application of tissue engineering. Human Adipose Derived Mesenchymal Stem Cells (hADMSC) is a multipotent cell which has osteogenic, chondrogenic, and adipogenic potential. It also has somany similar characteristics with Bone Marrow stem cells (BMSCs) but hADMSC has higher proliferation rate compared to BMSCs.Inspite of this, another ability of biofactors is gene engineering. Aim. This study aimed to analyze mandibular bone density from the synthesis of scaffold-hADMSC with the mean gray scale and the mandibular bone thickness (Micro-CT).Material and Methods. This research involved several processes, namely synthetic scaffold manufacturing process, differentiation and characterization of hADMSC, and Micro-CT. Results. The results of the marked expression of the characterization of hADMSCand analysis of the mean gray scale and mandibular thickness (Micro-CT) to mandibular bone density in synthetic scaffold-hADMSC showed to be significant. Conclusions. Synthetic scaffold-hADMSC can increase mandibular bone density after Micro-CT analysis.