Analysis of the Development of B-Cell Precursors in Day Three Incubated Chicken Embryos

Maslichah Mafruchati, Wan Iryani Wan Ismail

Research output: Contribution to journalArticlepeer-review


In mammals, birds, and amphibians, the B lineage of lymphoid cells first arise during embryogenesis and are distinguished by their capacity to produce immunoglobulin.For the purpose of researching the development of the B-cell repertoire and the development of self-tolerance, these early B-cell precursors are of utmost importance.The genetic and/or microenvironmental variables that control the beginning of immunoglobulin synthesis in embryonic haemopoietic cells are, however, poorly understood.The ontogeny of B-cell precursors in chicken embryos from day three of incubation was examined in this work.The terms "ontogeny, B-cell, precursors, chicken embryos, incubation"were used in a thorough literature search in the PubMed, NCBI, and Google Scholar databases.After all articles were picked based on the inclusion and exclusion criteria, 38 papers that satisfied the criteria for inclusion were collected.The study's findings show that clglarge basophilic hemopoietic stem cells and cIg+ small lymphoid B-cell precursors are two types of migrant cells that appear to enter the embryonic bursa of Fabricius.Hence, B lymphopoiesis does not only take place in the bursa of Fabricius in the avian embryo.Although the yolk sac and the hemopoietic tissues around the dorsal aorta are strong candidates, the identity of the extra-bursal location remains unknown.Hence, general haemopoietic organs may serve as the initial site of B lymphopoiesis in both birds and mammals.Only later in the course of avian development do the bursal follicles become accessible and take over.

Original languageEnglish
Pages (from-to)1569-1575
Number of pages7
JournalBiomedical and Pharmacology Journal
Issue number3
Publication statusPublished - Sept 2023


  • B-Cell
  • Chicken Embryos
  • Incubation
  • Precursors
  • Public Health


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