TY - JOUR
T1 - Analysis of risks of gastric cancer by gastric mucosa among Indonesian ethnic groups
AU - Miftahussurur, Muhammad
AU - Waskito, Langgeng Agung
AU - Syam, Ari Fahrial
AU - Nusi, Iswan Abbas
AU - Dewa Nyoman Wibawa, I.
AU - Rezkitha, Yudith Annisa Ayu
AU - Siregar, Gontar
AU - Yulizal, O. K.
AU - Akil, Fardah
AU - Uwan, Willy Brodus
AU - Simanjuntak, David
AU - Waleleng, Jimmy Bradley
AU - Saudale, Alexander Michael Joseph
AU - Yusuf, Fauzi
AU - Maulahela, Hasan
AU - Richardo, Marselino
AU - Rahman, Abdul
AU - Namara, Yoma Sari
AU - Sudarmo, Eko
AU - Adi, Pangestu
AU - Maimunah, Ummi
AU - Setiawan, Poernomo Boedi
AU - Fauzia, Kartika Afrida
AU - Doohan, Dalla
AU - Uchida, Tomohisa
AU - Lusida, Maria Inge
AU - Yamaoka, Yoshio
N1 - Funding Information:
National Institutes of Health (DK62813) and the Grants-in- Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan (221S0002, 16H06279, 15H02657, 18KK0266, 19H03473 and 16H05191) (YY). It was also supported by the Japan Society for the Promotion of Science Institutional Program for Coreto- Core Program; B. Africa-Asia Science Platform (YY). LAW, DD, and KAF are doctoral students supported by MEXT Scholarship Program for 2015, 2016, and 2017, respectively. In addition, The Ministries of Research, Technology and Higher Education in the World Class Professor Program (123.4/D2.3/KP/ 2018) also supported this research (MM and MIL).
Publisher Copyright:
© 2019 Miftahussurur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/5
Y1 - 2019/5
N2 - Indonesia is a big country with multiethnic populations whose gastric cancer risks have not been elucidated. We performed a nationwide survey and obtained histological specimens from 1053 individuals in 19 cities across the country. We examined the gastric mucosa, the topography, the atrophic gastritis risk factors, and the gastric cancer risk scores. Almost half (46.1%) of the patients with dyspeptic symptoms had histological abnormalities; chronic (36.3%) and atrophic gastritis (28.9%) being the most frequent. Individuals of the Timor ethnicity had the highest prevalence of acute (52.6%) and chronic gastritis (68.4%), even those negative for H. pylori. Our topographic analysis showed the majority of patients had predominantly antral acute and chronic gastritis. A multivariate logistic regression model showed age (Odds ratio [OR], 1.107), Timor ethnicity (OR, 8.531), and H. pylori infection (OR, 22.643) as independent risk factors for presence of atrophic gastritis. In addition, the gastric cancer risk score was highest in those from Timor, Papuan, and Bugis ethnic populations. Overall, Indonesia is a low-risk gastric cancer country. However, several ethnic groups displayed severe gastric mucosa symptoms suggesting policy makers should focus on those ethnic groups to perform gastric cancer screenings and to eradicate H. pylori.
AB - Indonesia is a big country with multiethnic populations whose gastric cancer risks have not been elucidated. We performed a nationwide survey and obtained histological specimens from 1053 individuals in 19 cities across the country. We examined the gastric mucosa, the topography, the atrophic gastritis risk factors, and the gastric cancer risk scores. Almost half (46.1%) of the patients with dyspeptic symptoms had histological abnormalities; chronic (36.3%) and atrophic gastritis (28.9%) being the most frequent. Individuals of the Timor ethnicity had the highest prevalence of acute (52.6%) and chronic gastritis (68.4%), even those negative for H. pylori. Our topographic analysis showed the majority of patients had predominantly antral acute and chronic gastritis. A multivariate logistic regression model showed age (Odds ratio [OR], 1.107), Timor ethnicity (OR, 8.531), and H. pylori infection (OR, 22.643) as independent risk factors for presence of atrophic gastritis. In addition, the gastric cancer risk score was highest in those from Timor, Papuan, and Bugis ethnic populations. Overall, Indonesia is a low-risk gastric cancer country. However, several ethnic groups displayed severe gastric mucosa symptoms suggesting policy makers should focus on those ethnic groups to perform gastric cancer screenings and to eradicate H. pylori.
UR - http://www.scopus.com/inward/record.url?scp=85065736812&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0216670
DO - 10.1371/journal.pone.0216670
M3 - Article
C2 - 31071187
AN - SCOPUS:85065736812
SN - 1932-6203
VL - 14
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e0216670
ER -
