Analysis of Intravoxel Incoherent Motion (IVIM) Diffusion Weighted Imaging Post-Processing Techniques to Determine Benign and Malignant Breast Lesions

Apparent Diffusion Coefficient values between benign and malignant breast lesions have overlapping values related to varying of b values. Intravoxel Incoherent Motion post processing techniques produces three coefficients, namely free molecular diffusion coefficient, the perfusion coefficient, and perfusion fraction which could improve the characterization of both lesions. The aim of this study is to analyze Intravoxel Incoherent Motion Diffusion Weighted Imaging post processing techniques to evaluate benign and malignant breast lesions. Thirteen raw data of breast Magnetic Resonance Imaging with contrast injection consists of two samples of benign and eleven samples of malignant lesions. It uses b values fifty, one hundred, two hundred, eight hundred, and one thousand second per millimeter square. All three coefficient values are obtained from Diffusion Weighted Imaging image by placing Region Of Interest on the most enhanced lesion area regarding to Dynamic Contrast Enhancement Image. After that Signal Intensity slope would be noted. This study reveals free molecular diffusion coefficient of malignant lesion is zero point seventy six plus or minus zero point fourteen and the other hand, one point forty six plus or minus zero point thirty nine in benign lesion. With the results that, there is significantly difference of free molecular diffusion coefficient between malignant and benign lesion, but not on perfusion coefficient and Signal Intensity slope. There is no overlapping of free molecular diffusion coefficient between benign and malignant breast lesion, so that it could be used to differentiate both lesion.