An Indonesian male with congenital hypogonadotropic hypogonadism: A case report and literature review

Leadri Surya Arrosy, Hermina Novida

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by insufficient gonadotropin-releasing hormone (GnRH) production. Case presentation: An Indonesian adolescent, 22 years old, Javanese ethnic, complained of a small penis, low sexual desire, fatigue, and anosmia since childhood. Medical history stated that the patient had low testosterone levels 7 years ago and received testosterone once. Testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were decreased. The testicular ultrasound result was bilateral microtestis, suspicious of bilateral hypoplasia of the epididymis. Brain MRI also supports the diagnosis of hypogonadotropic hypogonadism, and the patient received Sustanon of 250 mg/2 weeks. The patient showed a good prognosis after 1 month of therapy. Discussion: The success of CHH therapy must be explored to improve its management. Conclusion: CHH in an Indonesian male shows a good prognosis with testosterone injection.

Original languageEnglish
Article number104720
JournalAnnals of Medicine and Surgery
Volume82
DOIs
Publication statusPublished - Oct 2022

Keywords

  • Congenital hypogonadotropic hypogonadism
  • Follicle-stimulating hormone
  • Luteinizing hormone
  • Testosterone

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