Amino acid determinants conferring stable sialidase activity at low pH for H5N1 influenza A virus neuraminidase

Tadanobu Takahashi, Chairul A. Nidom, Mai thi Quynh Le, Takashi Suzuki, Yoshihiro Kawaoka

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Avian influenza A viruses (IAVs) and human 1918, 1957, and 1968 pandemic IAVs all have neuraminidases (NAs) that are stable at low pH sialidase activity, yet most human epidemic IAVs do not. We examined the pH stability of H5N1 highly pathogenic avian IAV (HPAI) NAs and identified amino acids responsible for conferring stability at low pH. We found that, unlike other avian viruses, most H5N1 IAVs isolated since 2003 had NAs that were unstable at low pH, similar to human epidemic IAVs. These H5N1 viruses are thus already human virus-like and, therefore, have the frequent infections of humans.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalFEBS Open Bio
Volume2
DOIs
Publication statusPublished - 2012

Keywords

  • Avian influenza A virus
  • H5N1
  • Highly pathogenic
  • Low-pH stability
  • Neuraminidase
  • Sialidase

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