@article{9822247e9fdf4be9957dcbe1844c97f0,
title = "Amino acid determinants conferring stable sialidase activity at low pH for H5N1 influenza A virus neuraminidase",
abstract = "Avian influenza A viruses (IAVs) and human 1918, 1957, and 1968 pandemic IAVs all have neuraminidases (NAs) that are stable at low pH sialidase activity, yet most human epidemic IAVs do not. We examined the pH stability of H5N1 highly pathogenic avian IAV (HPAI) NAs and identified amino acids responsible for conferring stability at low pH. We found that, unlike other avian viruses, most H5N1 IAVs isolated since 2003 had NAs that were unstable at low pH, similar to human epidemic IAVs. These H5N1 viruses are thus already human virus-like and, therefore, have the frequent infections of humans.",
keywords = "Avian influenza A virus, H5N1, Highly pathogenic, Low-pH stability, Neuraminidase, Sialidase",
author = "Tadanobu Takahashi and Nidom, {Chairul A.} and {Quynh Le}, {Mai thi} and Takashi Suzuki and Yoshihiro Kawaoka",
note = "Funding Information: We thank Susan Watson for scientific editing. This work was supported, in part, by MEXT/JSPS KAKENHI Grant Number ( C; 23590549 ), by a Sasakawa Scientific Research Grant from The Japan Science Society, by a SRI (Shizuoka Research Institute) academic research grant, by the Global COE Program from the Japan Society for the Promotion of Science, by ERATO (Japan Science and Technology Agency), by a grant-in-aid for Specially Promoted Research from the Ministries of Education, Culture, Sports, Science, and Technology, by grants-in-aid from Health, Labor, and Welfare of Japan, by the Japan Initiative for Global Research Network on Infectious Diseases, and by National Institute of Allergy and Infectious Disease Public Health Service research grants. ",
year = "2012",
doi = "10.1016/j.fob.2012.08.007",
language = "English",
volume = "2",
pages = "261--266",
journal = "FEBS Open Bio",
issn = "2211-5463",
publisher = "Wiley-Blackwell",
}
