Amino Acid and Proximate Analysis of Type-1 Collagen from Sea Cucumber and Tilapia-Skin and its Potential Application as Artificial Tendon

Arifia Safira, Cinta Atsa Mahesa Rani, Roro Ayu Puspitasari, Anindyta Kirana Putri Ayuningtyas, Yayang Amru Mahendra, Agus Purnomo, Faisal Fikri, Shekhar Chhetri, Muhammad Thohawi Elziyad Purnama

Research output: Contribution to journalArticlepeer-review

Abstract

Tendon injury is a medical indication that requires surgical therapy and prolonged recovery. Collagen plays a crucial role in the wound healing process. Collagen maintains homeostasis, interacts with platelets, and enhances cellular components. Most living organisms consist of collagen components as fibrillar proteins. In this study, the potential properties of type-1 collagen from sea cucumber and Tilapia-skin were evaluated depend on proximate analysis, amino acid composition, and moisture-absorption ability. The result showed that Tilapia-skin has a higher protein and fat composition compared to the sea cucumber. In contrast, moisture, ash, and yield composition showed higher for sea cucumber compared to Tilapia-skin. Meanwhile, based on amino acid analysis was revealed that proline, alanine, methionine, isoleucine, leucine, phenylalanine, and lysine were lower on sea cucumber compared to Tilapia-skin. In conclusion, both type-1 collagen material from sea cucumber and Tilapia-skin might be developed as a biomaterial for tendon injury. It is crucial that further studies be carried out to emphasize the potential of biodegradable and bio-replaceable materials using the in vivo model.

Original languageEnglish
Pages (from-to)358-361
Number of pages4
JournalPharmacognosy Journal
Volume14
Issue number4
DOIs
Publication statusPublished - Jul 2022

Keywords

  • Artificial tendon
  • Collagen
  • Marine biodiversity
  • Sea cucumber
  • Tilapia-skin

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