Alteration in Resting EEG for Different Dosage of Methadone Treatment

Artha I. Simbolon, Ulfah Nadiya, M. Agung Suhendra, Dwi Esti Kusumandari, Arjon Turnip, Siti Aminah Sobana, Arifah Nur Istiqomah

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Methadone has a neurophysiological effect in humans that can be analyzed quantitatively using an electroencephalogram (EEG). This study considers the effects of neurophysiological for delta, theta, alpha, and beta frequency band in all brain regions for two dosage ranges categorized as low dose (<100 mg) and high dose (>100 mg). The EEG signals of methadone patients are compared to the healthy subject to analyze the brain alteration after one-hour methadone administration using resting condition (open-eyes and closed-eyes) test protocol. This study uses 17 channels with 10-20 international standard systems for the electrode caps. This study uses 4th order Butterworth bandpass (0.3-70 Hz) filter and STFT Hanning-window to determine the power spectral density. The results indicate that for low dose methadone patient, all the power spectrum of frequency band increase relative to healthy subjects in all brain regions and still follow the trend of healthy subjects' EEG oscillation. Nevertheless, for high dose methadone patients, only the delta and theta that follow the trend of healthy subject's EEG oscillation, but the value of power spectrum decreases relative to healthy subjects in all brain regions. Further, the power spectrum of alpha and beta for high dose methadone patients has different values for different brain regions.

Original languageEnglish
Title of host publication2019 International Conference of Computer Science and Information Technology, ICoSNIKOM 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728154237
DOIs
Publication statusPublished - Nov 2019
Externally publishedYes
Event2nd International Conference of Computer Science and Information Technology, ICoSNIKOM 2019 - Medan, Indonesia
Duration: 28 Nov 201929 Nov 2019

Publication series

Name2019 International Conference of Computer Science and Information Technology, ICoSNIKOM 2019

Conference

Conference2nd International Conference of Computer Science and Information Technology, ICoSNIKOM 2019
Country/TerritoryIndonesia
CityMedan
Period28/11/1929/11/19

Keywords

  • EEG.
  • STFT
  • high dose
  • low dose
  • methadone

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