Alstiphyllanines A-D, indole alkaloids from Alstonia macrophylla

Yusuke Hirasawa, Hiroko Arai, Kazumasa Zaima, Rice Oktarina, Abdul Rahman, Wiwied Ekasari, Aty Widyawaruyanti, Gunawan Indrayanto, Noor Cholies Zaini, Hiroshi Morita

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Four new alkaloids, alstiphyllanines A-D (1-4), were isolated from Alstonia macrophylla, and their structures were determined by MS and 2D NMR analyses. Alkaloids 1-4 showed moderate antiplasmodial activity against Plasmodium falciparum and vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

Original languageEnglish
Pages (from-to)304-307
Number of pages4
JournalJournal of Natural Products
Issue number2
Publication statusPublished - Feb 2009


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