TY - JOUR
T1 - Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
AU - Ramli, Rosdayati Alino
AU - Pudjiastuti, Pratiwi
AU - Tjahjandaric, Tjitjik S.
AU - Lie, Wilford
AU - Rattanajak, Roonglawan
AU - Kamchonwongapaisan, Sumalee
AU - Pyne, Stephen G.
N1 - Publisher Copyright:
© 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
PY - 2015/3
Y1 - 2015/3
N2 - Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.
AB - Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.
KW - Anti-malarial
KW - Cytotoxicity
KW - Human acetylcholinesterase
KW - Javastemonine A and B
KW - Stemona javanica
UR - https://www.scopus.com/pages/publications/84920085367
U2 - 10.1016/j.phytol.2014.12.009
DO - 10.1016/j.phytol.2014.12.009
M3 - Article
AN - SCOPUS:84920085367
SN - 1874-3900
VL - 11
SP - 157
EP - 162
JO - Phytochemistry Letters
JF - Phytochemistry Letters
ER -
