TY - JOUR
T1 - Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
AU - Ramli, Rosdayati Alino
AU - Pudjiastuti, Pratiwi
AU - Tjahjandaric, Tjitjik S.
AU - Lie, Wilford
AU - Rattanajak, Roonglawan
AU - Kamchonwongapaisan, Sumalee
AU - Pyne, Stephen G.
N1 - Funding Information:
We thank the Ministry of Higher Education of Malaysia and the Islamic and Science University of Malaysia for a Postgraduate Scholarship to R. A. R. and the University of Wollongong for financial support. We also thank Rudijanta Tjahja Nograha, Head of National Conservation Beaurau of Alas Purwo, East of Java for permission to sample the plant material.
Publisher Copyright:
© 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
PY - 2015/3
Y1 - 2015/3
N2 - Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.
AB - Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.
KW - Anti-malarial
KW - Cytotoxicity
KW - Human acetylcholinesterase
KW - Javastemonine A and B
KW - Stemona javanica
UR - http://www.scopus.com/inward/record.url?scp=84920085367&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2014.12.009
DO - 10.1016/j.phytol.2014.12.009
M3 - Article
AN - SCOPUS:84920085367
SN - 1874-3900
VL - 11
SP - 157
EP - 162
JO - Phytochemistry Letters
JF - Phytochemistry Letters
ER -